ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Fighting Heartburn and Gerd Naturally – And Safely!

Safely Reduce a Common Cause of Stomach Distress

 
Print Page
Email Article

Genetic linkage analysis of multicase families with fibromyalgia (FM) syndrome

  [ 105 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 2, 1999


OBJECTIVE: Based on the reports of familial aggregation of
fibromyalgia (FM) syndrome, we investigated its possible
genetic linkage to HLA by studying multicase families.

METHODS: Forty Caucasian multicase families with a diagnosis
of FM (American College of Rheumatology criteria) in 2 or more
first degree relatives were investigated. Eighty- five
affected and 21 unaffected members of 41 sibships were
studied. Depression symptomology was assessed by Zung
Self-rating Depression Scale (SDS). HLA typing was performed
for A, B, and DRB 1 alleles, and haplotypes were determined
with no knowledge of the subject's diagnosis. We investigated
genetic linkage to the HLA region by evaluating sibships in
multicase families.

RESULTS: Sibship analysis showed
significant genetic linkage of FM to the HLA region (p =
0.028). Subgroup analysis was also performed for 17 families
where the proband was also noted to have depression (with an
SDS index value > or =60). We found that the presence of
depression did not influence the observed results (p = 0.22).

CONCLUSION:. Our study of 40 multicase families confirms
existence of a possible gene for FM that is linked with the
HLA region. Our results should be regarded as preliminary and
their independent confirmation by other studies is warranted.

Yunus MB, Khan MA, Rawlings KK, Green JR, Olson JM, Shah S




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Clinically Studied Joint Relief Product for FM & ME/CFS Clinically Studied Joint Relief Product for FM & ME/CFS
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map