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Genetics & pathophysiology of affective disorders: relationship to Fibromyalgia (FM)

  [ 56 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 5, 1998


Depression and fibromyalgia (FM) share common symptoms, indicating a
close relationship between both disorders. FM patients
frequently present symptoms of major depression. Genetic
epidemiological studies show that genetic transmission is one
important component. Molecular genetic studies are on the way;
the serotonin transporter promoter gene seems to be associated
with neurotic anxiety and FM. Biochemical studies related to
the serotonin and norepinephrine neurotransmission are
disturbed in both disorders. This view is supported by the
response to treatment with antidepressants.

Ackenheil M




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