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Plasma levels on nociceptin in female Fibromyalgia (FM) syndrome patients

  [ 10 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 5, 1998


Fibromyalgia syndrome (FMS) is a frequent pain disorder in women.
The pathophysiologic mechanism behind this disorder is still
unexplained; however, alterations in both monoamines,
neuropeptides and in the stress axis have been found. This
study was designed to determine the levels of the newly
discovered neuropeptide nociceptin in hormonally different FMS
patients and corresponding controls. The results showed that
the nociceptin concentrations of the patients were lower than
in controls. It also showed decreased levels with significant
differences between the cyclic patients in the luteal phase of
the menstrual cycle, compared to the corresponding controls.
Our results suggest that the perturbed nociceptin
concentrations of the FMS patients may be linked to both the
sex hormones and to the stress system and that these changes
might be one of several possible pathophysiologic mechanisms
involved in the FMS.

Anderberg UM, Liu Z, Berglund L, Nyberg F




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