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Neuroendocrine abnormalities in fibromyalgia (FM) & related disorders

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By Crofford LJ • www.ProHealth.com • June 2, 1998


Fibromyalgia (FM) and related syndromes are poorly understood
disorders that share symptoms such as pain, fatigue, sleep
disturbances, and psychological distress. These syndromes are
more common in women, and they are associated with
psychological or physical stressors. The neuroendocrine axes
are essential physiologic systems that allow for communication
between the brain and the body. Interconnections among the
neuroendocrine axes lead to coordinate regulation of these
systems in both a positive and negative fashion. Several
neuroendocrine axes have been shown to be dysfunctional in
patients with FM. Although we do not yet understand the
relationship between the reported disturbances of
neuroendocrine function and the development or maintenance of
FM and related syndromes, the authors have proposed that these
abnormalities are important in symptomatic manifestations.
This article reviews data showing disturbances of the
neuroendocrine axes in FM and proposes a hypothesis of the
development and maintenance of FM related to neuroendocrine
disturbances.




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