ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Acupressure reduced fatigue in breast cancer survivors

Omega-3 fatty acid stops known trigger of lupus

What’s Fenugreek Good For?

Print Page
Email Article

Researchers Identify Protein that Allows Nervous System Communication

  [ 24 votes ]   [ Discuss This Article ] • September 9, 2002

Researchers at UT Southwestern Medical Center at Dallas have identified one of the key proteins involved in the establishment of the central nervous system. They’ve found that the protein, SynCAM, plays a major role in the formation of synapses, or the specialized junctions at which a neuron communicates with a target nerve cell. Neurons receive and send electrical signals over long distances within the body. The process of synaptic transmission drives communication between neurons in the brain and underlies all brain function.

This is only the second study that cites the initial events leading to the formation of synapses in the central nervous system, said Dr. Thomas Biederer, a postdoctoral researcher in the Center for Basic Neuroscience and lead author of the study, reported in the Aug. 30 issue of Science.

“Until this discovery very little was known about how neurons form synapses with each other,” Biederer said. “We defined how the initial contact points are being developed and from there we can figure out how the young nervous system grows into an active network.”

Synaptic formation is important in both newborns and adults. In newborns, synapses are formed rapidly and abundantly. The central nervous system, which encompasses the brain and spinal cord, establishes a stable network by keeping those that are functionally important and eliminating those that are not important. In adults, there is constant remodeling of neurons and synapses that relates to ongoing processes like learning and memory.

In neurological diseases such as Alzheimer’s and Parkinson’s, there is a loss of neurons and synapses, Biederer said. A better understanding of the ingredients of trans-synaptic signaling could lead to new disease treatments.

“One can speculate that the detrimental effects of these diseases can be balanced by a molecule such as SynCAM that can induce new synapses,” Biederer said. “Other possible applications could include therapies for spinal cord injuries.”

The researchers identified the protein by searching the mouse genome for a candidate molecule that could form a bridge between neurons and recruit synaptic components. A model for synaptic transmission was created by artificially inducing synapses and performing a functional characterization using cultured neurons from laboratory mice. This is the first study in which a model was designed to artificially induce synaptic transmission, Biederer said.

When SynCAM was over expressed the researchers reported an increase in spontaneous synaptic structures and spontaneous synaptic activity by as much as three-fold. When this function of SynCAM was interrupted, there was a decrease in the number of synapses and activity.

“We are now at the very core of what creates active neuronal networks and a functional central nervous system,” Biederer said.

The researchers are currently studying other proteins that may be involved in this process.

Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map