ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Lutein — An Important Nutrient for Eye and Brain Health

White Camphor Oil: The Purest Camphor Oil

Taurine: Facts About This Crucial Amino Acid

Lutein, found in leafy greens, may counter cognitive aging

Vitamin D3 Versus D2

 
Print Page
Email Article

New Study Reports Positive Results for New Alzheimer’s Treatment Memantine

  [ 101 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 11, 2002


Researchers from Forest Laboratories Inc., announced that in a recently completed 6 month placebo-controlled study of patients with moderate-to-severe Alzheimer's disease, a significant benefit was observed when memantine treatment was added to their background donepezil (Aricept®) therapeutic regimen.

The Phase III trial was a double-blind, parallel arm, placebo-controlled design in which a total of 403 patients with moderate-to-severe Alzheimer's disease were randomized to 6 months of treatment with either memantine 20 mg per day or placebo in addition to their donepezil therapy. To be eligible for study inclusion, patients must have been treated with a stable dose of donepezil for at least 6 months prior to randomization. The primary outcome assessments were the Severe Impairment Battery (SIB) scale, a measure of cognition and the Alzheimer's disease Cooperative Study Inventory – Activities of Daily Living (ADCS-ADL) scale, a measure of daily function. A physician global assessment (CIBIC-Plus) was also performed.

In this study, at the end of the 6 month treatment period, memantine, at a daily dose of 20 mg plus donepezil, was statistically significantly superior to placebo plus donepezil treatment on both primary outcome measures, the ADCS-ADL (function) and the SIB (cognition). In addition, the CIBIC-Plus scores (global measure) demonstrated a statistically significant benefit for the memantine treatment group compared to the placebo treatment group.

“The study results were consistent with the favorable effects previously demonstrated after memantine treatment alone in this same population as previously reported by Reisberg et al. in the Merz sponsored U.S. trial Study 9605 and show the beneficial effects of memantine treatment combined with donepezil as compared to donepezil alone." said Lawrence S. Olanoff, M.D., Ph.D., Executive Vice President - Forest Laboratories. "Further, the study showed that memantine in combination with donepezil produced improvement over the six month study period in cognition in contrast with most other treatment studies in Alzheimer's patients which have demonstrated only a slowing of the expected decline in cognition."

Forest is conducting three additional placebo-controlled trials to further confirm memantine's cognitive and functional benefits and to evaluate its efficacy in patients with mild-to-moderate as well as moderate-to-severe stages of the disease. Results from these investigations are expected in 2003.



Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Energy NADH™ 12.5mg Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
Relief for Dry, Itchy Skin Caused by Fibromyalgia Relief for Dry, Itchy Skin Caused by Fibromyalgia
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map