ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

Scientifically-designed fasting diet lowers risks for major diseases

How One Tiny Molecule Turned into One Huge Health Breakthrough

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Research on Astaxanthin Demonstrates Significant Whole Body Benefits

Humans have three times more brown body fat

Nutrients Boost Stem Cell Function

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

Dietary prebiotics improve sleep, buffer impacts of stress, says study

 
Print Page
Email Article

New Study Reports Positive Results for New Alzheimer’s Treatment Memantine

  [ 101 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 11, 2002


Researchers from Forest Laboratories Inc., announced that in a recently completed 6 month placebo-controlled study of patients with moderate-to-severe Alzheimer's disease, a significant benefit was observed when memantine treatment was added to their background donepezil (Aricept®) therapeutic regimen.

The Phase III trial was a double-blind, parallel arm, placebo-controlled design in which a total of 403 patients with moderate-to-severe Alzheimer's disease were randomized to 6 months of treatment with either memantine 20 mg per day or placebo in addition to their donepezil therapy. To be eligible for study inclusion, patients must have been treated with a stable dose of donepezil for at least 6 months prior to randomization. The primary outcome assessments were the Severe Impairment Battery (SIB) scale, a measure of cognition and the Alzheimer's disease Cooperative Study Inventory – Activities of Daily Living (ADCS-ADL) scale, a measure of daily function. A physician global assessment (CIBIC-Plus) was also performed.

In this study, at the end of the 6 month treatment period, memantine, at a daily dose of 20 mg plus donepezil, was statistically significantly superior to placebo plus donepezil treatment on both primary outcome measures, the ADCS-ADL (function) and the SIB (cognition). In addition, the CIBIC-Plus scores (global measure) demonstrated a statistically significant benefit for the memantine treatment group compared to the placebo treatment group.

“The study results were consistent with the favorable effects previously demonstrated after memantine treatment alone in this same population as previously reported by Reisberg et al. in the Merz sponsored U.S. trial Study 9605 and show the beneficial effects of memantine treatment combined with donepezil as compared to donepezil alone." said Lawrence S. Olanoff, M.D., Ph.D., Executive Vice President - Forest Laboratories. "Further, the study showed that memantine in combination with donepezil produced improvement over the six month study period in cognition in contrast with most other treatment studies in Alzheimer's patients which have demonstrated only a slowing of the expected decline in cognition."

Forest is conducting three additional placebo-controlled trials to further confirm memantine's cognitive and functional benefits and to evaluate its efficacy in patients with mild-to-moderate as well as moderate-to-severe stages of the disease. Results from these investigations are expected in 2003.



Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Ultra ATP+, Double Strength Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map