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Migraine chronobiology

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By Fox AW, Davis RL • www.ProHealth.com • June 10, 1998


This study was undertaken to determine whether migraine
attacks exhibits circadian, menstrual, or seasonal variations
in frequency and, thus, to characterize more precisely this
relapsing, remittent, pleomorphic disease. An analysis of 3582
well-documented migraine attacks in 1698 adults was
undertaken. The demographics of the study population
accurately represented the known epidemiology of the disease.
Migraine attacks started more frequently between 4 AM and 9 AM
and within the first few days after onset of menses; this
migraine periodicity is strongest amongst women not using oral
contraceptives. Seasonal periodicity, if any, is clearly
weaker than circadian or menstrual. These chronobiological
features may assist in the differential diagnosis of migraine
from premenstrual headache and fibromyalgia.




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