ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Meta-analysis adds evidence to association between omega-3 supplementation and lower heart rate

Friendly User's Guide for the Timing of Nutritional Supplements

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Mediterranean diet associated with lower risk of aggressive prostate cancer

Print Page
Email Article

Anticardiolipin antibodies in childhood rheumatic disorders

  [ 16 votes ]   [ Discuss This Article ]
By Gedalia A, Molina JF, Garcia CO, Doggett S, Espinoza LR, Gharavi AE • • January 6, 1998

Anticardiolipin antibodies (aCL) have been reported to occur in a
wide variety of autoimmune and non-autoimmune disorders in
adults. Our objective was to investigate the prevalence and
isotype distribution of aCL and its relationship with the
features of antiphospholipid syndrome (APS) in childhood
rheumatic disorders.

Between November 1995 and May 1996, all patients
who visited our paediatric rheumatology clinic whose
guardians signed a consent form participated in the study. The
study population included 106 patients (36 systemic lupus
erythematosus (SLE), 28 juvenile rheumatoid arthritis (JRA),
11 fibromyalgia, 7 sarcoidosis, 5 dermatomyositis, 3 rheumatic
fever (RF), 3 vasculitis, 2 scleroderma, and 11
miscellaneous). aCL measurements were performed by enzyme
linked immunoabsorbent assay (ELISA). All patients were
carefully evaluated for symptoms and signs of APS. Eighteen of
the 106 patients (17%) were tested positive for one or more of
the three aCL isotypes. In SLE, aCL were found positive in 13
of 36 (37%); in JRA 2 of 28 (7%); in sarcoidosis 2 of 7; and
in RF 1 of 3. aCL of IgG isotype were found positive in 16
patients (11 SLE, 2 sarcoidosis, 2 JRA, and 1 RF). This
isotype was usually detected at low titers (16-24 GPL). aCL of
IgM isotype were found positive in five patients (2
sarcoidosis, 2 SLE, 1 JRA), and aCL of IgA isotype were found
positive in only three patients (2 SLE, 1 sarcoidosis).

Clinical features of APS were rarely seen in our SLE
population and were not associated with the presence of aCL.
None of the patients in the other groups exhibited any
clinical manifestations of APS. In conclusion, aCL were found
in 37% of our childhood SLE patients as compared with only 7%
in JRA. These were mostly aCL of IgG isotype of low titers and
therefore were not associated with the main features of APS.
Prospective studies with a larger sample size may be needed to
ascertain the exact prevalence and clinical significance of
aCL in childhood-onset SLE.

Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida®

Article Comments

Be the first to comment on this article!

Post a Comment

Optimized Curcumin Longvida with Omega-3

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map