ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Nutrients Boost Stem Cell Function

Humans have three times more brown body fat

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

Dietary prebiotics improve sleep, buffer impacts of stress, says study

Ylang Ylang Oil Not Only Soothes Your Skin, but Your Mind as Well

Exercises to Help Prevent Urinary Incontinence

 
Print Page
Email Article

The clinical features of Rheumatoid Arthritis (RA)

  [ 98 votes ]   [ Discuss This Article ]
By Grassi W, De Angelis R, Lamanna G, Cervini C • www.ProHealth.com • May 5, 1998


Rheumatoid arthritis (RA) is a chronic inflammatory disease
characterized by progressive damage of synovial-lined joints
and variable extra-articular manifestations. Tendon and bursal
involvement are frequent and often clinically dominant in
early disease. RA can affect any joint, but it is usually
found in metacarpophalangeal, proximal interphalangeal and
metatarsophalangeal joints, as well as in the wrists and knee.

Articular and periarticular manifestations include joint
swelling and tenderness to palpation, with morning stiffness
and severe motion impairment in the involved joints. The
clinical presentation of RA varies, but an insidious onset of
pain with symmetric swelling of small joints is the most
frequent finding. RA onset is acute or subacute in about 25%
of patients, but its patterns of presentation also include
palindromic onset, monoarticular presentation (both slow and
acute forms), extra-articular synovitis (tenosynovitis,
bursitis), polymyalgic-like onset, and general symptoms
(malaise, fatigue, weight loss, fever). The palindromic onset
is characterized by recurrent episodes of oligoarthritis with
no residual radiologic damage, while the polymyalgic-like
onset may be clinically indistinguishable from polymyalgia
rheumatica in elderly subjects. RA is characteristically a
symmetric erosive disease. Although any joint, including the
cricoarytenoid joint, can be affected, the distal
interphalangeal, the sacroiliac, and the lumbar spine joints
are rarely involved. The clinical features of synovitis are
particularly apparent in the morning. Morning stiffness in and
around the joints, lasting at least 1 h before maximal
improvement is a typical sign of RA. It is a subjective sign
and the patient needs to be carefully informed as to the
difference between pain and stiffness. Morning stiffness
duration is related to disease activity. Hand involvement is
the typical early manifestation of rheumatoid arthritis.

Synovitis involving the metacarpophalangeal, proximal
interphalangeal and wrist joints causes a characteristic
tender swelling on palpation with early severe motion
impairment and no radiologic evidence of bone damage. Fatigue,
feveret, weight loss, and malaise are frequent clinical signs
which can be associated with variable manifestations of
extra-articular involvement such as rheumatoid nodules,
vasculitis, hematologic abnormalities, Felty's syndrome, and
visceral involvement. Although there is no laboratory test to
exclude or prove the diagnosis of rheumatoid arthritis,
several laboratory abnormalities can be detected. Abnormal
values of the tests for evaluation of systemic inflammation
are the most typical humoral features of RA. These include:
erythrocyte sedimentation rate, acute phase proteins and
plasma viscosity. Erythrocyte sedimentation rate and
C-reactive protein provide the best information about the
acute phase response. The C-reactive protein is strictly
correlated with clinical assessment and radiographic changes.

Plain film radiography is the standard investigation to assess
the extent of anatomic changes in rheumatoid arthritis
patients. The radiographic features of the hand joints in
early disease are characterized by soft tissue swelling and
mild juxtaarticular osteoporosis. In the the past 10 years,
ultrasonography has gained acceptance for studying joint,
tendon and bursal involvement in RA. It may improve the early
clinical assessment and the follow-up of these patients,
showing such details as synovial thickening even within finger
joints. Other imaging techniques, such as magnetic resonance,
computed tomography and scintigraphy may provide useful
information about both the features and the extent for
anatomic damage in selected rheumatoid arthritis patients. The
natural history of the disease is poorly defined; its clinical
course is fluctuating and the prognosis unpredictable. RA is
an epidemiologically relevant cause of disability. An adequate
early treatment of RA may alter the disease process.




Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map