ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Study bodes well for low-carb eaters

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Omega Fix for Obesity: How the Right Fats Fight Fat

Potential of Quercetin in the Treatment of Melanoma

How Pomegranate May Protect Against Cancer

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Trimming the spare tire: Canola oil may cut belly fat

 
Print Page
Email Article

Function of the hypothalamic-pituitary-adrenal axis in patients with fibromyalgia (FM) & low back pain

  [ 116 votes ]   [ Discuss This Article ]
By Griep EN, Boersma JW, Lentjes EG, Prins AP, van der Korst JK, de Kloet ER • www.ProHealth.com • July 5, 1998


OBJECTIVE: We suggested fibromyalgia (FM) is a disorder
associated with an altered functioning of the stress-response
system. This was concluded from hyperreactive pituitary
adrenocorticotropic hormone (ACTH) release in response to
corticotropin-releasing hormone (CRH) and to insulin induced
hypoglycemia in patients with FM. In this study, we tested the
validity and specificity of this observation compared to
another painful condition, low back pain.

METHODS: We
recruited 40 patients with primary FM (F:M 36:4), 28 patients
(25:3) with chronic noninflammatory low back pain (LBP), and
14 (12:2) healthy, sedentary controls. A standard 100 microg
CRH challenge test was performed with measurement of ACTH and
cortisol levels at 9 time points. They were also subjected to
an overnight dexamethasone suppression test, followed by
injection of synthetic ACTH1-24. At 9 AM, the patients divided
in 2 groups, received either 0.025 or 0.100 microg ACTH/kg
body weight to test for adrenocortical sensitivity. Basal
adrenocortical function was assessed mainly by measurement of
24 h urinary excretion of free cortisol.

RESULTS: Compared to
the controls, the patients with FM displayed a hyperreactive
ACTH release in response to CRH challenge (ANOVA interaction
effect p = 0.001). The mean ACTH response of the patients with
low back pain appeared enhanced also, but to a significantly
lesser extent (p = 0.02 at maximum level) than observed in the
patients with FM. The cortisol response was the same in the 3
groups. Following dexamethasone intake there were 2 and 4
nonsuppressors in the FM and LBP groups, respectively. The
very low and low dose of exogenous ACTH1-24 evoked a dose and
time dependent cortisol response, which, however, was not
significantly different between the 3 groups. The 24 h urinary
free cortisol levels were significantly lower (p = 0.02) than
controls in both patient groups; patients with FM also
displayed significantly lower (p < 0.05) basal total plasma
cortisol than controls.

CONCLUSION: The present data validate
and substantiate our preliminary evidence for a dysregulation
of the HPA axis in patients with FM, marked by mild
hypocortisolemia, hyperreactivity of pituitary ACTH release to
CRH, and glucocorticoid feedback resistance. Patients with LBP
also display hypocortisolemia, but only a tendency toward the
disrupted HPA features observed in the patients with FM. We
propose that a reduced containment of the stress- response
system by corticosteroid hormones is associated with the
symptoms of FM.




Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map