ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Relief for IBS, Colitis, Crohn’s And More

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Restoring NAD+ could reduce DNA damage accumulation

What Benefits Can You Derive From Patchouli Oil?

Astaxanthin Is a Longevity Promoter

 
Print Page
Email Article

Moderately High Homocysteine Tied to Alzheimer’s, Stroke Risk

  [ 127 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 9, 2002


Moderate elevations of homocysteine are associated with a more than five-fold increase in the risk for stroke and almost triple the risk for Alzheimer's disease, according to research in the October issue of Stroke.

Homocysteine is an amino acid believed to be toxic to blood vessels. Several studies have linked high blood levels of homocysteine to increased heart attack risk. This study found that homocysteine levels in patients with stroke, Alzheimer's disease or vascular dementia were consistently higher than homocysteine levels in age-matched healthy volunteers.

"Since B vitamins and foods fortified with folate can reduce homocysteine levels, this study suggests that B vitamin supplementation may be appropriate for most adults. It warrants a large placebo-controlled study of folate, and vitamins B6 and B12 in people at risk from dementia and stroke," says lead author Stephen P. McIlroy, Ph.D., a lecturer in geriatric medicine at Queen's University in Belfast, Ireland.

McIlroy and his colleagues studied 83 Alzheimer's patients (average age 77); 78 patients with dementia caused by poor blood flow to the brain, a condition called vascular dementia (average age 77); 64 stroke patients (average age 74) and 71 healthy volunteers (average age 74).

There is some disagreement among scientists about what constitutes an elevated homocysteine level. Here, researchers designated the upper quartile of homocysteine levels of the healthy volunteers – 13.3 micromoles per liter (ìmol/L) or higher – as an elevated level.

They also collected data on education, diet, blood pressure, cholesterol, and smoking history. Several of these factors are associated with the risk for Alzheimer's disease, and smoking directly affects homocysteine levels, he says. The researchers also used DNA testing to determine if any of the subjects had a variation in the gene methylenetetrahydrofolate (MTHFR), which can adversely affect folate metabolism.

After correcting for other risk factors, elevated homocysteine was associated with a 2.9 times greater risk for Alzheimer's disease than risk in volunteers with lower levels of homocysteine. The stroke risk was 5.5 times greater, and for vascular dementia, it was 4.9 times greater. These findings were not related to having the MTHFR mutated gene.

In an accompanying editorial, Amos D. Korczyn, M.D., of the department of neurology at Tel-Aviv University Medical School in Ramat-Aviv, Israel, notes that there is no ultimate proof that homocysteine causes stroke or dementia. He says that elevated homocysteine could theoretically be the result of stroke or dementia. Additionally, he notes that poor diet – which is common in old age, particularly among people with dementia – may raise homocysteine.

However, Korcyzn also says it may now be appropriate to recommend that elderly people and particularly those with higher risk of vascular disease or dementia take vitamins B12 and folate.

"Since dietary habits are so different among people, it may be appropriate to recommend 2 to 5 mg folic acid and a similar dose of vitamin B12 daily," he says. "This recommendation is based on the known safety of both vitamins, which do not have side effects even if used in excessive amounts, and their low cost." McIlroy notes that in the United States many foods, especially cereals, are fortified with folate but this is not the case in the United Kingdom. Even with the fortified foods, a daily vitamin B supplement may be warranted especially after a stroke, he says.



Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Ultra ATP+, Double Strength FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map