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A randomized, double-blind, placebo-controlled study of moclobemide & amitriptyline in the treatment of fibromyalgia (FM) in females without psychiatric disorder

  [ 65 votes ]   [ Discuss This Article ]
By Hannonen P, Malminiemi K, Yli-Kerttula U, Isomeri R, Roponen P • www.ProHealth.com • December 5, 1998


OBJECTIVE: To study the usefulness of moclobemide and amitriptyline
in the treatment of fibromyalgia (FM) in females without
psychiatric disorder.

METHODS: In the present four centre, 12
week study, 130 female FM patients not suffering from
psychiatric disorders were randomized to receive amitriptyline
(AMI; 25 37.5 mg), moclobemide (MOCLO; 450-600 mg) or
identical placebo.

RESULTS: Seventy-four, 54 and 49 per cent
of patients on AMI, MOCLO and placebo, respectively, were
judged as responders. The patients on AMI also managed best
regarding the respective improvements during the trial in
general health, pain, sleep quality and quantity, and fatigue
on visual analogue scales (VAS), the areas of the Nottingham
Health Profile (NHP), as well as in the three Sheehan's
functional disability scales. In the within-group comparisons,
MOCLO also improved pain assessed both on VAS and on the NHP
pain dimension, but the improvement was invalidated by the
poor success of the drug with regard to sleep. The
tolerabilities of all three drugs were comparable.

CONCLUSION:
The study indicates that MOCLO may not be helpful in FM
patients free from clinically meaningful psychiatric problems.




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