ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Astaxanthin Is a Longevity Promoter

Meta-analysis links vitamin D deficiency with increased risk of mortality during 10.5 year median pe...

Prevent Or Reverse Diabetes: An Amazing Herbal Intervention

Exercise and Vitamin D Better Together for Heart Health

VIDEO: Essential Oils for Weight Loss

Can Valerian Root Help You Sleep Better?

Eight servings of veggies a day is clearly best for the heart

Can Ginkgo Give Your Brain a Boost?

Fighting Statin-Induced Diabetes with CoQ10

The Many Wonders of Calming Sandalwood Oil

 
Print Page
Email Article

Can Alzheimer's Disease Be Slowed by Shunting Cerebrospinal Fluid?

  [ 103 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 28, 2002


In a first study of its kind, researchers from Stanford University, the University of Washington (Seattle), and the Barrow Neurological Institute in Phoenix tested the hypothesis that improving the circulation of cerebrospinal fluid (CFS), the liquid surrounding the brain and spinal cord, will slow or stop the progression of dementia in people with Alzheimer's disease. The study is published in the October 22 issue of Neurology, the scientific journal of the American Academy of Neurology.

CSF shunting for dementia was first described in 1969 and, despite early optimism, was largely abandoned due to mixed clinical results and an unacceptably high incidence of adverse events related to the shunts. Recent clinical studies in which CSF shunting was used to treat patients with symptomatic hydrocephalus, a disease in which CSF increases in the brain causing enlargement of the skull, demonstrated a coincidental lack of cognitive decline in patients who also had Alzheimer's dementia.

"We speculated that, although the subjects described in these recent studies may have had two unrelated diseases, both Alzheimer's and normal pressure hydrocephalus may be part of a disease spectrum whose primary determinant is CSF circulatory failure," says study author Gerald Silverberg, MD, of Stanford University.

Silverberg and colleagues conducted a prospective, randomized, controlled clinical trial in which an investigational low-flow ventriculoperitoneal (VP) shunt was evaluated in Alzheimer's patients. The surgically implanted shunts drained CSF at a constant rate much lower than pervious studies to minimize the potential for over-drainage and to optimize constant CSF flow.

Subjects were screened and randomized into test and control groups, with 12 completing the shunt testing, and 11 patients tested as a comparison group. Both control and shunted patients were tested at baseline and every three months using the National Adult Reading Test, the Mattis Dementia Rating Scale and the Mini Mental Status Examination.

There were no substantial differences in age or severity of dementia between the shunted patients and the control group at baseline. However, the shunted patients experienced relative stability while the control group demonstrated a fairly robust decline in cognitive function over the 12 months of the study. The number of shunted patients in this study was too small to make broad claims about the safety of the shunt device, though the outcomes are encouraging.

"Our preliminary safety and efficacy data, including the outstanding questions they present, suggest that more definitive testing is appropriate," concludes Silverberg. A larger, multi-center, controlled clinical trial is now underway.



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
The Super Antioxidant for Brain, Joint and Heart Health The Super Antioxidant for Brain, Joint and Heart Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map