ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Lutein — An Important Nutrient for Eye and Brain Health

White Camphor Oil: The Purest Camphor Oil

Taurine: Facts About This Crucial Amino Acid

Lutein, found in leafy greens, may counter cognitive aging

Vitamin D3 Versus D2

 
Print Page
Email Article

Low-dose lidocaine suppresses experimentally induced hyperalgesia in humans

  [ 31 votes ]   [ Discuss This Article ]
By Koppert W, Zeck S, Sittl R, Likar R, Knoll R, Schmelz M • www.ProHealth.com • December 6, 1998


BACKGROUND: The antinociceptive effects of systemically
administered local anesthetics have been shown in various
conditions, such as neuralgia, polyneuropathy, fibromyalgia,
and postoperative pain. The objective of the study was to
identify the peripheral mechanisms of action of low-dose local
anesthetics in a model of experimental pain.

METHODS: In a first experimental trial, participants (n=12) received
lidocaine systemically (a bolus injection of 2 mg/kg in 10 min
followed by an intravenous infusion of 2 mg x kg(-1) x h(-1)
for another 50 min). In a second trial, modified intravenous
regional anesthesia was administered to exclude possible
central analgesic effects. In one arm, patients received an
infusion of 40 ml lidocaine, 0.05%; in their other arm, 40 ml
NaCl, 0.9%, served as a control. In both trials, calibrated
tonic and phasic mechanical and chemical (histamine) stimuli
were applied to determine differentially the impairment of
tactile and nociceptive perception.

RESULTS: Mechanical sensitivity to touch, phasic mechanical
stimuli of noxious intensity, and heat pain thresholds remained
unchanged after systemic and regional application of the anesthetic.
In contrast, histamine-induced itch (intravenous regional
anesthesia), axon reflex flare (systemic treatment), and
development of acute mechanical hyperalgesia during tonic
pressure (12 N; 2 min) of an interdigital web was
significantly suppressed after both treatments.

CONCLUSIONS: Increasing painfulness during sustained pinching
has been attributed to excitation and simultaneous sensitization of
particular Adelta- and C-nociceptors. This hyperalgesic
mechanism seems to be particularly sensitive to low
concentrations of lidocaine. These findings confirm clinical
experience with lidocaine in pain states dominated by
hyperalgesia.




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida® FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Inflammation Disrupts Memory - What Can You Do to Protect Your Brain? Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map