ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Curcumin: The All In One Solution, Part 2

CoQ10 — A Nutritional Powerhouse for Mitochondrial Health

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Use Burdock Oil to Promote Healthy Hair Growth

Why You Should Take Your Apple Cider Vinegar at Night

AMA journal associates iron deficiency with hearing loss

Lutein linked to preservation of crystallized intelligence

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Zinc eaten at levels found in biofortified crops reduces 'wear and tear' on DNA

 
Print Page
Email Article

Low-dose lidocaine suppresses experimentally induced hyperalgesia in humans

  [ 31 votes ]   [ Discuss This Article ]
By Koppert W, Zeck S, Sittl R, Likar R, Knoll R, Schmelz M • www.ProHealth.com • December 6, 1998


BACKGROUND: The antinociceptive effects of systemically
administered local anesthetics have been shown in various
conditions, such as neuralgia, polyneuropathy, fibromyalgia,
and postoperative pain. The objective of the study was to
identify the peripheral mechanisms of action of low-dose local
anesthetics in a model of experimental pain.

METHODS: In a first experimental trial, participants (n=12) received
lidocaine systemically (a bolus injection of 2 mg/kg in 10 min
followed by an intravenous infusion of 2 mg x kg(-1) x h(-1)
for another 50 min). In a second trial, modified intravenous
regional anesthesia was administered to exclude possible
central analgesic effects. In one arm, patients received an
infusion of 40 ml lidocaine, 0.05%; in their other arm, 40 ml
NaCl, 0.9%, served as a control. In both trials, calibrated
tonic and phasic mechanical and chemical (histamine) stimuli
were applied to determine differentially the impairment of
tactile and nociceptive perception.

RESULTS: Mechanical sensitivity to touch, phasic mechanical
stimuli of noxious intensity, and heat pain thresholds remained
unchanged after systemic and regional application of the anesthetic.
In contrast, histamine-induced itch (intravenous regional
anesthesia), axon reflex flare (systemic treatment), and
development of acute mechanical hyperalgesia during tonic
pressure (12 N; 2 min) of an interdigital web was
significantly suppressed after both treatments.

CONCLUSIONS: Increasing painfulness during sustained pinching
has been attributed to excitation and simultaneous sensitization of
particular Adelta- and C-nociceptors. This hyperalgesic
mechanism seems to be particularly sensitive to low
concentrations of lidocaine. These findings confirm clinical
experience with lidocaine in pain states dominated by
hyperalgesia.




Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ FibroSleep™ Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Breakthrough Form of Magnesium Enhances Memory and Cognitive Function Breakthrough Form of Magnesium Enhances Memory and Cognitive Function
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map