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Low levels of serum acylcarnitine in Chronic Fatigue Syndrome (CFS) & chronic hepatitis type C, but not seen in other diseases

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By Kuratsune H, Yamaguti K, Lindh G, Evengard B, Takahashi M, Machii T, Matsumura K, Takaishi J, Kawata S, Langstrom B, Kanakura Y, Kitani T, Watanabe Y • www.ProHealth.com • July 3, 1998


Recently, we found a serum acylcarnitine (ACR) deficiency in
Japanese patients with chronic fatigue syndrome (CFS). To
clarify whether this ACR abnormality is a characteristic of
CFS or not, we also studied the levels of serum carnitine in
Swedish subjects. Both serum ACR and free carnitine (FCR)
levels in normal healthy subjects were quite different between
Japanese (n=131) and Swedish people (n=46) (p<0.001). However,
it is confirmed that Swedish patients with CFS (n=57) also had
serum ACR deficiency (p<0.001). When we studied the levels of
serum ACR and FCR in Japanese patients with various kinds of
diseases (CFS, hematological malignancies, chronic
pancreatitis, hypertension, diabetes mellitus, chronic
hepatitis type C, psychiatric diseases), a significant
decrease in the levels of serum ACR was only found in patients
with CFS and chronic hepatitis type C (p<0.001). Therefore, we
concluded that ACR deficiency in serum might be a
characteristic abnormality in only certain types of diseases.




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