ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Scientifically-designed fasting diet lowers risks for major diseases

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

A Little Zinc Goes a Long Way

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Get the Most From Your Green Tea

Iron (And More) For Lasting, Natural Energy

Metabolic syndrome increases the need for vitamin E

Supplement combo improves bone density, mood, in postmenopausal women

 
Print Page
Email Article

First animal model for pancreatic cancer may lead to early detection of disease

  [ 71 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 10, 2003


Scientists have made a major discovery that may revolutionize the detection and treatment of one of the most deadly cancers known to man. The research, published online in Cancer Cell, describes the creation and characterization of the first animal model for ductal pancreatic cancer and provides extraordinary insight into development of future diagnostic tests for early disease detection as well as potential therapeutic strategies.

Pancreatic cancer is an aggressive and highly lethal cancer, with a less than 5% chance of surviving just five years past diagnosis. The disease begins to spread almost immediately, making treatment nearly impossible. Understanding the pathology of how pancreatic cancer develops is essential to finding a way to prevent or treat this disease. Drs. Sunil R. Hingorani and David A. Tuveson from the Abramson Family Cancer Research Institute at the University of Pennsylvania genetically engineered mice to express a mutant gene, KRAS, which is commonly associated with pancreatic cancer. The mice developed pancreatic intraepithelial neoplasms (PanIN), a condition that preceded development of full-blown invasive pancreatic cancer.

Interestingly, coauthors Drs. Emanuel F. Petricoin and Lance A. Liotta at the FDA/NCI observed that the mice with PanINs had a unique group of proteins in their blood that were not found in disease-free mice. This protein signature provided an accurate and noninvasive means to detect early pancreatic cancer in mice, showing that in principle such an approach could work in humans at high risk for developing pancreatic cancer.

The mice represent the very first animal model that faithfully mimics noninvasive and invasive pancreatic ductal cancer. They also provide solid evidence that PanINs are a precursor to invasive pancreatic cancer. Perhaps one of the most significant findings is the complement of proteins that are unique to the blood of animals with PanINs. "There are currently no tests with sufficient sensitivity and specificity to detect pancreatic cancer early enough to attempt a cure, and no test of any kind exists to identify premalignant disease. Because of the super-aggressive nature of this disease, the only hope for cure comes from the ability to identify the preinvasive condition. Our research identifies a protein signature that can signal the earliest stage of this disease and may even be useful to identify therapeutic targets in pancreatic cancer," explains Dr. Tuveson.



Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Optimized Curcumin Longvida® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map