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The detoxification enzyme systems

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By Liska DJ • www.ProHealth.com • June 20, 1998


The human body is exposed to a wide array of xenobiotics in
one s lifetime, from food components to environmental toxins
to pharmaceuticals, and has developed complex enzymatic
mechanisms to detoxify these substances. These mechanisms
exhibit significant individual variability, and are affected
by environment, lifestyle, and genetic influences. The
scientific literature suggests an association between impaired
detoxification and certain diseases, including cancer,
Parkinson's disease, fibromyalgia, and chronic fatigue/immune
dysfunction syndrome. Data regarding these hepatic
detoxification enzyme systems and the body s mechanisms of
regulating them suggests the ability to efficiently detoxify
and remove xenobiotics can affect these and other chronic
disease processes. This article reviews the myriad
detoxification enzyme systems, their regulatory mechanisms,
and the dietary, lifestyle, and genetic factors influencing
their activities, as well as laboratory tests available to
assess their functioning.




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