ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

Free Testosterone Predicts Memory, Cognition in Older Men

  [ 100 votes ]   [ Discuss This Article ] • November 20, 2002

Older men with higher levels of free, or unbound, testosterone circulating in their bloodstreams have better visual and verbal recall and perform spatial tasks more adeptly than their peers, according to investigators at the National Institute on Aging (NIA). The study identifies a potential biological factor that one day could be used to protect against decline in memory and other cognitive skills in later life.

“Although we can’t firmly establish a causal relationship without further study, this finding suggests that there may be hormonal modulation of cognitive abilities as people get older. Clearly, having higher levels of circulating free testosterone is associated with a reduced risk of certain types of memory loss,” said Susan Resnick, Ph.D., an investigator in the NIA’s Laboratory of Personality and Cognition, and corresponding author of the study, published in the November 2002 issue of The Journal of Clinical Endocrinology & Metabolism.

Dr. Resnick, Scott Moffat, Ph.D., and their colleagues evaluated the testosterone levels of 407 men, ages 50 and older, who participated in the Baltimore Longitudinal Study of Aging (BLSA). The investigators then correlated free and total testosterone levels—measured over an average of 10 years—with the men’s performances on memory and other cognitive tests.

In the body, testosterone tends to bind with sex hormone binding gobulin (SHBG). But some testosterone remains freely circulating in the bloodstream. Unlike the SHBG-bound form of the hormone, free testosterone can circulate into the brain and affect nerve cells, Dr. Resnick said. Total testosterone is a measure of both free and SHBG-bound forms of the hormone. Of these measures, only free testosterone was significantly associated with higher scores on verbal and visual memory tests, such as recalling word lists and drawing a recently seen image. Free testosterone was also linked to high scores on a spatial test in which participants were asked to determine if rotated shapes were the same or different.

“Based on our results, testosterone levels are associated with selective and very specific effects on some aspects of cognition, including memory,” Dr. Resnick said.

In men, testosterone is produced in the testes, the reproductive glands that also produce sperm. As men age, their testes often produce somewhat less testosterone than they did during adolescence and early adulthood, when production of this hormone peaks.

Based on BLSA data, as many as 68 percent of men older than 70 have low levels of free testosterone. But while prescription testosterone replacement therapy is available, it may not be advisable for most older men because many effects of hormone supplementation remain unclear. It is not yet known, for instance, if testosterone replacement increases the risk of prostate cancer, the second leading cause of cancer death among men. In addition, studies suggest that supplementation might trigger excessive red blood cell production in some men. This side effect can thicken blood and increase a man's risk of stroke.

“We still have much to learn,” Dr. Resnick said. “Until we know much more about the fundamental effects of sex hormones on the aging brain and other parts of the body, testosterone supplementation is not a prudent choice for older men seeking to improve their memory and cognitive performance.”

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map