ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

16 Tips from 16 Years Sick

Fibromyalgia Fare Fit for All Seasons

New Study Shows Artificial Sweeteners Lead to Diabetes

Essential Oils — An Effective and Healthy Option to Treat Headaches

Antioxidant treatment could halt neurodegeneration in early Parkinson's

Higher vitamin D levels associated with less severe disease in NAFLD patients

Krill Oil: Make This Omega-3 Supplement Part of Your Health Regimen

How zinc helps fight esophageal cancer

Everything You Need to Know About Black Cohosh

Low vitamin D levels predict ED in diabetics

 
Print Page
Email Article

Lower serum activity of prolyl endopeptidase in fibromyalgia (FM) is related to severity of depressive symptoms & pressure hyperalgesia

  [ 35 votes ]   [ Discuss This Article ]
By Maes M, Libbrecht I, Van Hunsel F, Lin AH, Bonaccorso S, Goossens F, De Meester I, De Clerck L, Biondi M, Scharpe S, Janca A • www.ProHealth.com • July 27, 1998


BACKGROUND: The aims of the present study were to examine
serum activities of peptidases, i.e. prolyl endopeptidase
(PEP) and dipeptidyl peptidase IV (DPP IV), in patients with
fibromyalgia and to examine the effects of subchronic
treatment with sertraline on these variables. METHOD: Serum
PEP and DPP IV activity were measured in 28 normal volunteers
and 21 fibromyalgia patients, classified according to the
American College of Rheumatology criteria. Tenderness at
tender points was evaluated by means of dolorimetry.
Fibromyalgia patients had repeated measurements of serum PEP
and DPP IV both before and after repeated administration of
sertraline or placebo for 12 weeks. RESULTS: Patients with
fibromyalgia had significantly lower serum PEP activity than
normal volunteers. There were significantly negative
correlations between serum PEP activity and severity of
pressure hyperalgesia and the non-somatic, cognitive symptoms
of the Hamilton Depression Rating Scale. Fibromyalgia patients
with severe pressure hyperalgesia had significantly lower PEP
activity than normal controls and fibromyalgia patients with
less severe hyperalgesia. Fibromyalgia patients with severe
non-somatic depressive symptoms had significantly lower serum
PEP activity than normal volunteers. There were no significant
changes in serum DPP IV activity in fibromyalgia. There were
no significant effects of repeated administration of
sertraline on serum PEP and DPP IV activity in patients with
fibromyalgia. CONCLUSIONS: The results show that fibromyalgia,
and aberrant pain perception and depressive symptoms in
fibromyalgia are related to lower serum PEP activity. It is
hypothesized that lower serum PEP activity may play a role in
the biophysiology of fibromyalgia through diminished
inactivation of algesic and depression-related peptides.




Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map