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Intestinal & extraintestinal symptoms in functional gastrointestinal disorders

  [ 47 votes ]   [ Discuss This Article ]
By Mayer EA, Fass R, Fullerton S • www.ProHealth.com • May 3, 1998


Functional gastrointestinal disorders such as irritable bowel
syndrome or functional dyspepsia have traditionally been
regarded as syndromes limited to the digestive system.
However, both clinical experience and published evidence show
that patients with such disorders also report a series of
other symptoms of physical distress, such as fibromyalgia and
irritable bladder and alterations in vital functions, such as
sleep, libido, appetite and energy level. Some of these
extraintestinal symptoms can be explained in the context of an
evolving comprehensive disease model which views functional
gastrointestinal disorders as manifestations of alterations in
the interactions between the nervous system, the viscera and
the musculoskeletal system. Alterations in central circuits
concerned with arousal, attention and fear, cognitions about
bodily symptoms and possible alterations in the hypothalamic
pituitary adrenal (HPA) axis may all contribute to the wide
range of symptoms reported by affected patients.




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