ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Scientifically-designed fasting diet lowers risks for major diseases

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Vitamin D deficiency increases risk of chronic headache

Get the Most From Your Green Tea

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Iron (And More) For Lasting, Natural Energy

Metabolic syndrome increases the need for vitamin E

Study provides new evidence that exercise is not key to weight control

 
Print Page
Email Article

Decreased nitric oxide-mediated natural killer cell activation in Chronic Fatigue Syndrome (CFS)

  [ 108 votes ]   [ Discuss This Article ]
By Ogawa M, Nishiura T, Yoshimura M, Horikawa Y, Yoshida H, Okajima Y, Matsumura I, Ishikawa J, Nakao H, Tomiyama Y, Kanayama Y, Kanakura Y, Matsuzawa Y • www.ProHealth.com • November 13, 1998


BACKGROUND: L-Arginine (L-Arg), one of the essential amino
acids, has been reported to have an immunomodulatory effect.
The precise mechanism of the L-Arg-induced natural killer (NK)
cell activation remains unresolved,and the effect of L-Arg on
NK cells in chronic fatigue syndrome (CFS) patients has not
been estimated.

METHODS: NK cell function was evaluated in 20
subjects with CFS and compared with that in 21 healthy
individuals.

RESULTS: In healthy control subjects, NK activity
was significantly increased after treatment with L-Arg, an NK
function enhancer, for 24 h, whereas the same treatment failed
to enhance NK activity in the CFS patients. We thus focused on
L-Arg metabolism, which involves nitric oxide (NO) production
through NO synthase (NOS). The expression of inducible NO
synthase (iNOS) transcripts in peripheral blood mononuclear
cells was not significantly different between healthy control
subjects and CFS patients. The L-Arg- mediated NK cell
activation was abolished by addition of NG-monomethyl-
L-arginine, an inhibitor for iNOS. Furthermore, incubation
with S- nitroso-N-acetyl-penicillamine, an NO donor,
stimulated NK activity in healthy control subjects but not in
CFS patients.

CONCLUSION: These results demonstrate that the
L-Arg-induced activation of NK activity is mediated by NO and
that a possible dysfunction exists in the NO- mediated NK cell
activation in CFS patients.




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Breakthrough Form of Magnesium Enhances Memory and Cognitive Function Breakthrough Form of Magnesium Enhances Memory and Cognitive Function

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map