ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

Meet Your Weight Loss Goals

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

AMA journal associates iron deficiency with hearing loss

Why the Mediterranean Diet Is so Successful

 
Print Page
Email Article

Folic Acid Supplementation, Prednisolone Prolong Methotrexate Use in Rheumatoid Arthritis Patients

  [ 78 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 5, 2004


About two-thirds of patients with rheumatoid arthritis (RA) treated with methotrexate remain on the drug after 5 years, Dutch investigators have found. Folic acid supplementation and prednisolone are associated with sustained use.

Dr. Monique Hoekstra and colleagues from Medisch Spectrum Twente in Enschede, the Netherlands, conducted chart reviews to collect data on demographic and clinical factors associated with long-term methotrexate use in patients with RA. Life table analysis and Cox regression analysis were performed to assess methotrexate "survival" and its relation to demographic variables and clinical features.

The researchers analyzed a total of 1072 methotrexate treatment episodes in 1022 RA patients. They report that the cumulative methotrexate survival probabilities after 5 years and 9 years were 64% and 50%, respectively.

The findings are published in the November issue of the Journal of Rheumatology.

Univariate analysis demonstrated a significant association between methotrexate survival probability and folic acid supplementation, the attending rheumatologist, concurrent prednisolone use, concurrent sulfasalazine use, and the number of previous disease-modifying antirheumatic drugs (DMARDs) used.

A significant difference in methotrexate survival with and without folic acid supplementation was observed (p < 0.001). The 5-year survival probability with and without folic acid supplementation was 67% and 31%, respectively.

Multivariate analysis showed that folic acid (p < 0.001), rheumatologist (p = 0.002), and concurrent prednisolone use (p = 0.005) remained significantly associated with methotrexate survival.

"Age, disease duration, body mass index, and creatinine clearance were not related to methotrexate survival," Dr. Hoekstra and colleagues report.

They point out that treatment strategies of individual rheumatologists also influence the ability of patients to remain on methotrexate.

Journal reference: J Rheumatol 2003;30:2325-2329.

Source: MedScape Rheumatology news, online at www.medscape.com.

For more information about arthritis treatments including alternative and complementary therapies, please visit www.ArthritisSupport.com.



Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ FibroSleep™ Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall
Breaking Through the Mental Fog Breaking Through the Mental Fog

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map