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Skeletal muscle abnormalities in patients with fibromyalgia (FM)

  [ 17 votes ]   [ Discuss This Article ]
By Olsen NJ, Park JH • • June 15, 1998

Widespread muscle pain and tender points are the most common
complaints of fibromyalgia patients, and the underlying
mechanisms responsible for these symptoms have been studied
intensively during the past decade. It has been suggested that
fatigue and pain may lead to decreased levels of physical
activity in many patients. The resulting deconditioned state
may itself contribute to muscle abnormalities. Associated
symptoms such as disturbed sleep, anxiety, depression, or
irritable bowel also may have a negative impact on muscle
function and level of daily activities. The important
interactions between the central nervous and musculoskeletal
systems may involve another element, the neuroendocrine
stress-response system. This review will consider both the
current state of knowledge and also future studies which might
be designed to answer more effectively the outstanding
questions regarding the underlying pathogenesis of

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