ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Astaxanthin Is a Longevity Promoter

Meta-analysis links vitamin D deficiency with increased risk of mortality during 10.5 year median pe...

Prevent Or Reverse Diabetes: An Amazing Herbal Intervention

Exercise and Vitamin D Better Together for Heart Health

VIDEO: Essential Oils for Weight Loss

Can Valerian Root Help You Sleep Better?

Eight servings of veggies a day is clearly best for the heart

Can Ginkgo Give Your Brain a Boost?

Fighting Statin-Induced Diabetes with CoQ10

The Many Wonders of Calming Sandalwood Oil

 
Print Page
Email Article

Cytokine dysregulation in the post-Q-fever fatigue syndrome

  [ 61 votes ]   [ Discuss This Article ]
By Penttila IA, Harris RJ, Storm P, Haynes D, Worswick DA, Marmion BP • www.ProHealth.com • August 26, 1998


The post-Q-fever fatigue syndrome (QFS) (inappropriate fatigue,
myalgia and arthralgia, night sweats, changes in mood and
sleep patterns) follows about 20% of laboratory-proven, acute
primary Q-fever cases. Cytokine dysregulation resulting from
chronic immune stimulation and modulation by persistence of
Coxiella burnetii cells or their antigens is hypothesized. We
studied cytokine release patterns of peripheral blood
mononuclear cells (PBMC) stimulated with various ligands in
short- term culture, from 18 patients with active QFS, and 27
controls: six with resolving QFS, five who had had acute
primary Q-fever without subsequent QFS, eight healthy Q-fever
vaccinees and eight healthy subjects without Q-fever antibody.
Conditioned media (CM) from PBMC stimulated in short-term
culture with Q-fever antigens, PHA or measles antigen (as an
unrelated antigen) were assayed for IL-2, IL-4, IL-5, IL- 6,
IL-10 and IFN gamma by AgEIA, and for IL-1 and TNF alpha/beta
by bioassay. Aberrant cytokine release patterns were observed
with PBMC from QFS patients when stimulated with Q-fever
antigens: an accentuated release of IL-6 which was
significantly [p = 0.01, non-parametric one- way analysis of
variance (ANOVA)] in excess of medians for all four control
groups. With IL-2, the number of responders in the active QFS
group was decreased relative to control groups (Fisher's exact
test, p = 0.01) whereas the number of IFN gamma responders was
increased (Fisher's exact test, p = 0.0008). Significant
correlations were observed between concentrations of IL-6 in
CM, total symptom scores, and scores for other key symptoms.




Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ FibroSleep™ Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map