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Chronic fatigue disorders: an inappropriate response to arginine vasopressin?

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By Peroutka SJ • www.ProHealth.com • June 10, 1998


Chronic fatigue disorders are characterized by a subjectively
defined group of symptoms such as chronic fatigue, mental
confusion, exertional malaise, weight changes, and/or diffuse
multi-joint pains. Significant clinical overlap exists between
chronic fatigue disorders and the syndrome of serum
inappropriate anti-diuretic hormone (SIADH). Both chronic
fatigue disorders and SIADH are characterized by lethargy and
mental confusion. Both disorders can be induced or exacerbated
by viral illnesses, physical exertion, emotional stress and/or
hypotension. Both can be treated with salt loading and
glucocorticoids. Therefore, altered water metabolism resulting
from inappropriate release and/or response to arginine
vasopressin (AVP) is proposed as a pathophysiological basis of
certain chronic fatigue disorders. Moreover, these data
suggest that salt loading and/or direct inhibition of AVP may
be an effective therapeutic approach in individuals with
chronic fatigue disorders.




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