ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

16 Tips from 16 Years Sick

Fibromyalgia Fare Fit for All Seasons

New Study Shows Artificial Sweeteners Lead to Diabetes

Essential Oils — An Effective and Healthy Option to Treat Headaches

Higher vitamin D levels associated with less severe disease in NAFLD patients

Krill Oil: Make This Omega-3 Supplement Part of Your Health Regimen

How zinc helps fight esophageal cancer

Everything You Need to Know About Black Cohosh

Low vitamin D levels predict ED in diabetics

The Cellular Enzyme That Promotes Longevity And Reduces Fat Storage

 
Print Page
Email Article

Fly Mutation Suggests Link to Human Brain Disease, Including Alzheimer’s

  [ 17 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 24, 2003


Greater insight into human brain disease may emerge from studies of a new genetic mutation that causes adult fruit flies to develop symptoms akin to Alzheimer's disease.

“This is the first fruit fly mutant to show some of the outward, physical manifestations common to certain major human neurodegenerative diseases,” said principal investigator Michael McKeown, a biology professor at Brown University.

A research team found the mutation in a gene they named “blue cheese.” Reporting in the Feb. 15 issue of the Journal of Neuroscience, the researchers describe blue cheese mutations that lead normal-appearing adult flies (genus Drosophila) to die early from extensive cell death in the brain, neural degeneration, and build-up of protein aggregates.

“These aggregates contain the Drosophila version of proteins that are the major components of plaques that form in the brains of human Alzheimer's patients,” said the study's lead author, biologist Kim D. Finley, of the Salk Institute for Biological Studies. “The presence of these proteins in human plaques is at times used as a diagnostic tool for Alzheimer's disease.”

Genes first identified in Drosophila are often named for a mutant characteristic, said Finley. “The first obvious feature that we noted in older mutant flies was the slow accumulation of dark protein aggregates throughout the brain,” she said. “This reminded us of moldy versions of marbled and veined cheeses, thus the name blue cheese.”

The protein encoded by blue cheese also identifies a new family of proteins present in humans and other vertebrates, as well as in flies, said McKeown. “Our work on blue cheese not only identifies a gene needed for adult neural survival, it also allows identification of the members of this new family,” he said.

Similar blue cheese genes are found in species ranging from worms to humans. The protein encoded by blue cheese – the “blue cheese protein” – may be involved in transport or degradation of proteins and in other brain functions, said the researchers. Fruit flies have similar, yet fewer genes, compared to humans. One of the quickest ways to learn about potential effects of genetic mutations in humans is to screen and sample mutant fly genes.

“Drosophila models have been developed that mimic many aspects of human neural degeneration, primarily by expression of mutant proteins known to cause disease in humans,” said Finley. “In turn these models have been used to identify additional genes involved with the degenerative process, allowing new insights that may result in potential treatments of these disorders.”

In many aspects of gene regulation, growth, differentiation and cell function, Drosophila and human proteins appear very similar and have highly similar actions, said McKeown.

“These observations alone suggest a high likelihood that alterations in human blue cheese will contribute to some degenerative disorders in humans,” he said. In fact, “analysis of the human genetic map shows that blue cheese gene is in a region associated with several familial neurodegenerative diseases,” said McKeown.

The study was funded by grants from the National Institutes of Health.



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Vitamin D3 Extreme™ FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Enhance Eyelashes Naturally Enhance Eyelashes Naturally
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map