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Morphologic aspects of fibromyalgia (FM)

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By Pongratz DE, Spath M • www.ProHealth.com • March 20, 1998


The most common morphological finding in muscle biopsis in
longstanding fibromyalgia is type II fiber atrophy. This can
be found in many other conditions such as disuse atrophy,
affections of the corticospinal tracts, steroid atrophy, and
other different neuromuscular disorders. An increase in lipid
droplets and a slight proliferation of mitochondria in type I
muscle fibers are correlated with the duration of
fibromyalgia. In some cases we could find some ragged red
fibers (RRF) which histochemically show a pronounced
accumulation of lipids and mitochondria and single fiber
defects of cytochrome-c-oxidase. In some fibromyalgia patients
with RRF, we could find deletions of the mitochondrial genoma.




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