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Normal melatonin levels in patients with fibromyalgia (FM) syndrome

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By Press J, Phillip M, Neumann L, Barak R, Segev Y, Abu-Shakra M, Buskila D • www.ProHealth.com • March 27, 1998


OBJECTIVE: To assess urine levels of melatonin measured by 6-
sulphatoxymelatonin (aMT6s) in patients with fibromyalgia
(FM).

METHODS: Nocturnal aMT6s urine levels were measured by
ELISA, in a sample of urine collected from 10 PM to 7 AM from
39 female patients with FM and 39 age matched healthy female
controls. All subjects were interviewed and assessed for
nonarticular tenderness, FM symptoms, quality of life, and
physical functioning.

RESULTS: Nocturnal aMT6s levels of
patients with FM were not statistically different from those
of controls: 16.7+/-9.2 vs 16.0+/-11.3 microg, respectively.
No association was observed between aMT6s levels of patients
with FM and disease duration, reproductive status, sleep and
mood disturbances.

CONCLUSION: Nocturnal urine aMT6s levels
were similar in patients with FM and controls. Studies are
needed to elucidate the possible role of melatonin in FM and
should include larger samples of newly diagnosed untreated
patients with FM.




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