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Advances in fibromyalgia (FM): possible role for central neurochemicals

  [ 29 votes ]   [ Discuss This Article ]
By Russell IJ • www.ProHealth.com • June 6, 1998


The neurophysiologic term allodynia has been applied to
fibromyalgia because people with that disorder experience pain
from pressure stimuli which are not normally painful. The
nociceptive neurotransmitters of animal studies are now
relevant to this human model of chronic, widespread pain.
Evidence is presented to implicate several chemical pain
mediators (including serotonin, substance P, nerve growth
factor, and dynorphin A) in the pathogenesis of fibromyalgia.
This perception is hopeful because it offers many new options
for the development of innovative therapy.




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