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Neurochemical pathogenesis of fibromyalgia (FM)

  [ 111 votes ]   [ Discuss This Article ]
By Russell IJ • www.ProHealth.com • March 5, 1998


In contrast with the situation just a few years ago, the most
widely accepted model for the pathogenesis of FMS now invokes
CNS mechanisms like nociception and allodynia rather than
pathologically painful muscles. The levels of platelet
serotonin and CSF substance P appear to be abnormal in
directions that could logically amplify pain perception. The
extent to which these mechanisms are unique to FMS will be
critical in determining the direction that future research
should take. Certainly, a better understanding of the cause of
FMS could represent an important step toward the development
of more effective therapy.




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