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Pharmacology of pain processing systems

  [ 15 votes ]   [ Discuss This Article ]
By Schadrack J, Zieglgansberger W • www.ProHealth.com • March 6, 1998


Integration of nociceptive signaling comprises peripheral,
spinal, and supraspinal sites of the nervous system. Various
excitatory or inhibitory neurotransmitter and--modulator
systems participate in pain processing and modulation. Chronic
pain states are associated with functional and structural
alterations of nociceptive pathways. The numerous dynamic
changes in the pharmacologically distinct systems offer novel
targets for selective pharmacotherapy.




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