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Effect of gamma-hydroxybutyrate on pain, fatigue, & the alpha sleep anomaly in patients with fibromyalgia (FM). Preliminary report

  [ 70 votes ]   [ Discuss This Article ]
By Scharf MB, Hauck M, Stover R, McDannold M, Berkowitz D • • October 22, 1998

OBJECTIVE: To evaluate the effects of using a
gamma-hydroxybutyrate (GHB) administered in divided doses at
night in 11 patients previously diagnosed with fibromyalgia

METHODS: Subjects completed daily diaries assessing
their pain and fatigue levels and slept in the sleep
laboratory before and one month after initiating GHB
treatment. Polysomnographic recordings were evaluated for
sleep stages, sleep efficiency and the presence of the alpha
anomaly in non-REM sleep.

RESULTS: There was a significant
improvement in both fatigue and pain, with an increase in slow
wave sleep and a decrease in the severity of the alpha

CONCLUSION: Further controlled studies are needed to
characterize the clinical improvement and the polysomnographic
changes we observed.

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