ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

How Bacopa Can Help Improve Your Cognitive Function

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Give Your Health a Much-Needed Boost With Geranium

The Role of Resveratrol in Achieving Optimal Health

Could Coconut Oil Help Reduce Antibiotics?

 
Print Page
Email Article

Blunted adrenocorticotropin & cortisol responses to corticotropin-releasing hormone stimulation in Chronic Fatigue Syndrome (CFS)

  [ 25 votes ]   [ Discuss This Article ]
By Scott LV, Medbak S, Dinan TG • www.ProHealth.com • June 9, 1998


Hypofunctioning of the pituitary-adrenal axis has been
suggested as the pathophysiological basis for chronic fatigue
syndrome (CFS). Blunted adrenocorticotropin (ACTH) responses
but normal cortisol responses to exogenous
corticotropin-releasing hormone (CRH), the main regulator of
this axis, have been previously demonstrated in CFS patients,
some of whom had a comorbid psychiatric disorder. We wished to
re-examine CRH activation of this axis in CFS patients free
from concurrent psychiatric illness. A sample of 14 patients
with CDC-diagnosed CFS were compared with 14 healthy
volunteers. ACTH and cortisol responses were measured
following the administration of 100 microg ovine CRH. Basal
ACTH and cortisol values did not differ between the two
groups. The release of ACTH was significantly attenuated in
the CFS group (P < 0.005), as was the release of cortisol (P <
0.05). The blunted response of ACTH to exogenous CRH
stimulation may be due to an abnormality in CRH levels with a
resultant alteration in pituitary CRH receptor sensitivity, or
it may reflect a dysregulation of vasopressin or other factors
involved in HPA regulation. A diminished output of
neurotrophic ACTH, causing a reduced adrenocortical secretory
reserve, inadequately compensated for by adrenoceptor
upregulation, may explain the reduced cortisol production
demonstrated in this study.




Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Optimized Curcumin Longvida® Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map