ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Relief for IBS, Colitis, Crohn’s And More

Can Magnesium Relieve Your Tinnitus?

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Resveratrol Proven to Slow Brain Aging

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Restoring NAD+ could reduce DNA damage accumulation

Whole-body vibration may be as effective as regular exercise

 
Print Page
Email Article

Blunted adrenocorticotropin & cortisol responses to corticotropin-releasing hormone stimulation in Chronic Fatigue Syndrome (CFS)

  [ 25 votes ]   [ Discuss This Article ]
By Scott LV, Medbak S, Dinan TG • www.ProHealth.com • June 9, 1998


Hypofunctioning of the pituitary-adrenal axis has been
suggested as the pathophysiological basis for chronic fatigue
syndrome (CFS). Blunted adrenocorticotropin (ACTH) responses
but normal cortisol responses to exogenous
corticotropin-releasing hormone (CRH), the main regulator of
this axis, have been previously demonstrated in CFS patients,
some of whom had a comorbid psychiatric disorder. We wished to
re-examine CRH activation of this axis in CFS patients free
from concurrent psychiatric illness. A sample of 14 patients
with CDC-diagnosed CFS were compared with 14 healthy
volunteers. ACTH and cortisol responses were measured
following the administration of 100 microg ovine CRH. Basal
ACTH and cortisol values did not differ between the two
groups. The release of ACTH was significantly attenuated in
the CFS group (P < 0.005), as was the release of cortisol (P <
0.05). The blunted response of ACTH to exogenous CRH
stimulation may be due to an abnormality in CRH levels with a
resultant alteration in pituitary CRH receptor sensitivity, or
it may reflect a dysregulation of vasopressin or other factors
involved in HPA regulation. A diminished output of
neurotrophic ACTH, causing a reduced adrenocortical secretory
reserve, inadequately compensated for by adrenoceptor
upregulation, may explain the reduced cortisol production
demonstrated in this study.




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map