ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Acupressure reduced fatigue in breast cancer survivors

Omega-3 fatty acid stops known trigger of lupus

What’s Fenugreek Good For?

Print Page
Email Article

Toxic Molecule May Provide Key for Developing Vaccine Against Degenerative Diseases

  [ 173 votes ]   [ Discuss This Article ] • April 28, 2003

University of California, Irvine (UCI) researchers have discovered an important similarity in the causes of cell degeneration and death in diseases such as Alzheimer's, Parkinson's, Huntington's, type II diabetes and CJD, suggesting that a single therapy could combat these different ailments.

UCI molecular biologists Charles Glabe and Rakez Kayed found that small toxic molecules believed to trigger cell damage in these diseases have a similar structure. The study, which appears in the April 18, 2003 issue of Science, implies that these molecules, called toxic soluble oligomers, share parallel functions, which makes them suitable targets for new drugs or vaccines that could halt progression of many degenerative diseases.

"This discovery will help focus attention on what may be the primary mechanism for degeneration and cell death," said Glabe, professor of molecular biology and biochemistry. "Whatever makes these molecules toxic is likely to be the same for all of the different types of oligomers in the different diseases."

During the progression of these degenerative diseases, proteins called amyloids accumulate as fibrils and begin to damage healthy cells. Oligomer molecules serve as intermediate building blocks during this fibril formation process, and recent studies have found that these oligomers constitute the toxic element that triggers this cell damage.

In the UCI study, the researchers applied an oligomer-specific antibody to amyloid proteins that have been identified in Alzheimer's, Parkinson's, Huntington's, type II diabetes and prion-related disease. They found that the antibody bound only with the oligomer molecules, but did not bind with the normal amyloid proteins or amyloid molecules in the fibrils. This was true across different diseases, even though the proteins that make up the molecules in these diseases are distinct.

"Antibodies recognize other molecules by a lock and key mechanism," Glabe said. "If the same lock can be opened by several different keys, you can be reasonably sure that the keys, in this case the amyloid oligomers, have the same shape or structure."

The UCI research team also found that the oligomer-specific antibody blocked the oligomers' abilities to kill cultured neuronal cells in all of the protein groups they studied. If the oligomer-specific antibody has the same protective effect in humans, it may be possible to develop a vaccine that will simultaneously protect people against several different degenerative diseases.

"Vaccination has already proven to be effective in preventing amyloid accumulation and loss of neuronal function in animal models of Alzheimer's disease, but human clinical trials of this vaccine were halted because of inflammatory side effects in a fraction of the patients," Glabe said. "Our antibody may be able to overcome these problems because it targets only these toxic oligomer molecules and not the normal proteins."

Assisting in the study were UCI molecular biologists Jennifer L. Thompson and Saskia C. Milton, UCI chemist Theresa M. McIntire, and Elizabeth Head and Carl W. Cotman of the UCI Institute for Brain Aging and Dementia. This work was supported by grants from the Larry L. Hillblom Foundation and the National Institutes of Health.

Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Breaking Through the Mental Fog Breaking Through the Mental Fog

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map