ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

Why the Mediterranean Diet Is so Successful

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

Wearable biosensors can flag illness, Lyme disease, risk for diabetes; low airplane oxygen

VIDEO: The Best Brain Foods That Help Increase Your Memory!

More evidence for calorie restriction’s longevity effect

Iron (And More) For Lasting, Natural Energy

Affordable Care Act made cancer screening more accessible for millions, study finds

 
Print Page
Email Article

Hyperexcitability in fibromyalgia (FM)

  [ 48 votes ]   [ Discuss This Article ]
By Sorensen J, Graven-Nielsen T, Henriksson KG, Bengtsson M, Arendt-Nielsen L • www.ProHealth.com • January 15, 1998


OBJECTIVE: Spontaneous chronic widespread pain in combination with
hyperalgesia to pressure stimuli is the hallmark of
fibromyalgia (FM). We tested whether muscular hyperalgesia can
exist in a muscle without spontaneous pain, which could
indicate a generalized hyperexcitability of the nociceptive
system in patients with FM.

METHODS: Twelve women with FM and
12 age matched female controls participated in this blind
study. Patients had no spontaneous pain in the anterior tibial
(AT) muscle. The pressure pain threshold was tested on the AT
muscle. The pain threshold to electrical single and repeated
stimulations of the skin and of the right AT muscle was
assessed. Pain was evoked in the left AT muscle by infusion of
sterile hypertonic saline (5.7%, 2.8 ml over 480 s). The
saline induced muscle pain intensity and duration were
assessed by continuous recordings on an electronic visual
analog scale (VAS), and the distribution of pain was assessed
on drawings. The sequence of electrical sensibility tests and
the infusion of hypertonic saline was randomized.

RESULTS:
Pressure pain thresholds were lower (p < 0.02) in patients
with FM compared to controls. Thresholds for pain evoked by
electrical stimulation at the skin were not significantly
different in the 2 groups. The pain threshold to repeated
intramuscular stimulation was significantly (p = 0.02) lower
for the patients with FM compared to the control group,
indicating that the temporal nociceptive summation was more
pronounced in patients with FM. This is an indication of
central sensitization (hyperexcitability). Infusion of
hypertonic saline evoked muscle pain with a longer duration (p
= 0.01) in patients with FM, and referred pain that spread to
a larger area (p = 0.002) than in controls. This is an
indication of central hyperexcitability.

CONCLUSION: There is
a state of central hyperexcitability in the nociceptive system
in FM. This hyperexcitability can be revealed by excitation of
intramuscular nociceptors in a muscle with no spontaneous
pain.




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra ATP+, Double Strength Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
Clinically Studied Joint Relief Product for FM & ME/CFS Clinically Studied Joint Relief Product for FM & ME/CFS
Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map