ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Relief for IBS, Colitis, Crohn’s And More

Can Magnesium Relieve Your Tinnitus?

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Resveratrol Proven to Slow Brain Aging

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Restoring NAD+ could reduce DNA damage accumulation

Whole-body vibration may be as effective as regular exercise

 
Print Page
Email Article

Immunohistochemical & molecular studies of serotonin, substance P, galanin, pituitary adenylyl cyclase-activating polypeptide,& secretoneurin in fibromyalgic muscle tissue

  [ 39 votes ]   [ Discuss This Article ]
By Sprott H, Bradley LA, Oh SJ, Wintersberger W, Alarcon GS, Mussell HG, Tseng A, Gay RE, Gay S • www.ProHealth.com • September 15, 1998


OBJECTIVE: Because former investigations have reported
abnormal changes in the expression of serotonin
(5-hydroxytryptamine [5-HT]) and substance P (SP) in serum and
cerebrospinal fluid, this study sought to determine whether
5-HT and pain-modulating neuropeptides (SP, galanin [GA],
pituitary adenylyl cyclase-activating polypeptide, and
secretoneurin) were expressed abnormally in the muscle tissue
of patients with fibromyalgia (FM).
METHODS: Snap-frozen
muscle tissue specimens (deltoid muscles) from 10 patients
with FM (mean disease duration 15 years) and from 10 healthy
control subjects were examined by reverse
transcriptase-polymerase chain reaction (RT-PCR) of RNA
preparations from muscle cells, and by immunohistochemistry
methods (alkaline phosphatase-anti-alkaline phosphatase and
immunogold-silver) using specific primers as well as
antibodies. When specific messenger RNA (mRNA) was detected by
RT-PCR, in situ RT-PCR was performed for mRNA localization.
RESULTS: Specific mRNA for the examined substances was absent
in 9 of 10 FM patients and in 10 of 10 controls. No
differences between the FM patients and controls could be
detected in the muscle tissue by immunohistochemistry. In 1 FM
patient, mRNA for the GA receptor could be shown.
CONCLUSION:
This study showed that 5-HT and neuropeptides are not produced
in the muscle of patients with FM, and therefore do not appear
to be involved in the peripheral induction of pain in this
chronic, painful disorder.




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida® Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map