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Immunohistochemical & molecular studies of serotonin, substance P, galanin, pituitary adenylyl cyclase-activating polypeptide,& secretoneurin in fibromyalgic muscle tissue

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By Sprott H, Bradley LA, Oh SJ, Wintersberger W, Alarcon GS, Mussell HG, Tseng A, Gay RE, Gay S • www.ProHealth.com • September 15, 1998


OBJECTIVE: Because former investigations have reported
abnormal changes in the expression of serotonin
(5-hydroxytryptamine [5-HT]) and substance P (SP) in serum and
cerebrospinal fluid, this study sought to determine whether
5-HT and pain-modulating neuropeptides (SP, galanin [GA],
pituitary adenylyl cyclase-activating polypeptide, and
secretoneurin) were expressed abnormally in the muscle tissue
of patients with fibromyalgia (FM).
METHODS: Snap-frozen
muscle tissue specimens (deltoid muscles) from 10 patients
with FM (mean disease duration 15 years) and from 10 healthy
control subjects were examined by reverse
transcriptase-polymerase chain reaction (RT-PCR) of RNA
preparations from muscle cells, and by immunohistochemistry
methods (alkaline phosphatase-anti-alkaline phosphatase and
immunogold-silver) using specific primers as well as
antibodies. When specific messenger RNA (mRNA) was detected by
RT-PCR, in situ RT-PCR was performed for mRNA localization.
RESULTS: Specific mRNA for the examined substances was absent
in 9 of 10 FM patients and in 10 of 10 controls. No
differences between the FM patients and controls could be
detected in the muscle tissue by immunohistochemistry. In 1 FM
patient, mRNA for the GA receptor could be shown.
CONCLUSION:
This study showed that 5-HT and neuropeptides are not produced
in the muscle of patients with FM, and therefore do not appear
to be involved in the peripheral induction of pain in this
chronic, painful disorder.




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