ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Curcumin: The All In One Solution, Part 2

CoQ10 — A Nutritional Powerhouse for Mitochondrial Health

How to Prevent Hearing Loss and Improve Your Hearing With Nutrition

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Use Burdock Oil to Promote Healthy Hair Growth

Why You Should Take Your Apple Cider Vinegar at Night

AMA journal associates iron deficiency with hearing loss

Lutein linked to preservation of crystallized intelligence

Zinc eaten at levels found in biofortified crops reduces 'wear and tear' on DNA

 
Print Page
Email Article

Range of antinuclear antibodies in

  [ 10 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 8, 1997


OBJECTIVE: To determine the range of antinuclear antibodies
(ANA) in "healthy" individuals compared with that in patients
with systemic lupus erythematosus (SLE), systemic sclerosis
(SSc; scleroderma), Sjogren's syndrome (SS), rheumatoid
arthritis (RA), or soft tissue rheumatism (STR).

METHODS: Fifteen international laboratories experienced in
performing tests for ANA by indirect immunofluorescence
participated in analyzing coded sera from healthy individuals
and from patients in the 5 different disease groups described above.
Except for the stipulation that HEp-2 cells should be used as
substrate, each laboratory used its own in-house methodology
so that the data might be expected to reflect the output of a
cross-section of worldwide ANA reference laboratories. The
sera were analyzed at 4 dilutions: 1:40, 1:80, 1:160, and 1:320.

RESULTS: In healthy individuals, the frequency of ANA
did not differ significantly across the 4 age subgroups
spanning 20-60 years of age. This putatively normal population
was ANA positive in 31.7% of individuals at 1:40 serum
dilution, 13.3% at 1:80, 5.0% at 1:160, and 3.3% at 1:320. In
comparison with the findings among the disease groups, a low
cutoff point at 1:40 serum dilution (high sensitivity, low
specificity) could have diagnostic value, since it would
classify virtually all patients with SLE, SSc, or SS as ANA
positive. Conversely, a high positive cutoff at 1:160 serum
dilution (high specificity, low sensitivity) would be useful
to confirm the presence of disease in only a portion of cases,
but would be likely to exclude 95% of normal individuals.

CONCLUSION: It is recommended that laboratories performing
immunofluorescent ANA tests should report results at both the
1:40 and 1:160 dilutions, and should supply information on the
percentage of normal individuals who are positive at these
dilutions. A low-titer ANA is not necessarily insignificant
and might depend on at least 4 specific factors. ANA assays
can be a useful discriminant in recognizing certain disease
conditions, but can create misunderstanding when the
limitations are not fully appreciated.

Tan EM, Feltkamp TE, Smolen JS, Butcher B, Dawkins R, Fritzler MJ, Gordon T, Hardin JA, Kalden JR, Lahita RG, Maini RN, McDougal JS, Rothfield NF, Smeenk RJ, Takasaki Y, Wiik A, Wilson MR, Koziol JA




Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map