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Circulating blood volume in Chronic Fatigue Syndrome (CFS)

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By Streeten D, Bell D • www.ProHealth.com • April 15, 1998


Source: J of CFS 1998;4(1):3-11.

Chronic fatigue syndrome (CFS) is an illness associated with severe
activity limitation and a characteristic pattern of symptoms
despite a relatively normal physical examination and routine
laboratory evaluation. The recent description of delayed
orthostatic hypotension in patients with CFS, and previous
findings of reduced red blood cell (RBC) mass in other
patients with orthostatic hypotension not known to have CFS,
led us to measure RBC mass and plasma volume in 19 individuals
(15 female, four male) will well characterized, severe CFS.

RBC mass was found to be significantly reduced (p < 0.001)
below the published normal range in the 15 women, being
subnormal in 14 (93.3%) of them as well as in two of the four
men. Plasma volume was subnormal in 10 (52.6%) patients and
total blood volume was below normal in 12 (63.2%). The high
prevalence and frequent severity of low RBC mass suggest that
this abnormality might contribute to the symptoms of CFS by
reducing the oxygen-carrying power of the blood reaching the
brain in many of these patients. [obtained from CFS News]




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