ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

Researchers find signs of lethal cell division in mouse models for AD

  [ 36 votes ]   [ Discuss This Article ] • May 19, 2003

For many years now, scientists have relied on genetically engineered mouse models of Alzheimer disease (AD) to chart new course for treatment and diagnosis. The best known (and best studied) of these are lines carrying extra copies of either the beta-amyloid precursor protein gene or the presenilin-1 gene in their genomes. These mutant genes are known to cause early-onset familial AD, an inherited form of the disease. These models have been highly successful in modeling the process of amyloid plaque deposition, the pathological signature of AD, and the mice develop behavioral defects. However, the models have been disappointing in that they fail to mimic the substantial loss of nerve cells normally occurring during the development of dementia in AD.

New work presented at the 6th International Conference for Alzheimer's Disease/Parkinson's Disease, in Seville, Spain, by researchers from the University Memory and Aging Center and the departments of Neuroscience and Genetics at Case Western Reserve University (CWRU) and University Hospitals of Cleveland (UHC) offers a major new insight into this discrepancy between the human and mouse conditions.

The laboratory of Karl Herrup, Ph.D., has previously reported that the neurons in the susceptible brain regions of AD begin a lethal attempt at cell division before they die. (Mature brain cells are not programmed to divide.) Furthermore, once the lethal cell division begins, the death process itself appears to take up to a year to complete.

Now, Yan Yang, Bruce Lamb, Ph.D., and Herrup of UHC and CWRU have examined the mouse models of AD engineered by Lamb and looked for signs of cell division, or cell cycle events. The team has discovered that, just like their human counterparts, the nerve cells which are at-risk for death in the mouse AD model duplicate their DNA. In other words, they make an attempt at cell division.

"We know that this is a bad decision for an adult nerve cell to make. It almost always dies when it tries to divide," says Herrup. "Finding that the disease process begins in the mouse in the same way that it does in the human means that the mouse model may be much better than we thought at first."

But why don't researchers see signs of neuron death? Yang suggests, "It may be that the mouse simply doesn't live long enough." The average life expectance of a laboratory mouse is a little over two years. If the long time interval between starting cell division and nerve cell death is the same in mouse and human, the death of the mouse at two years may well block any chance researchers would have to see the actual cell death process start.

"Nonetheless, knowing that the underlying mechanism of cell death is the same means that experimental therapies can be tested productively in these model systems," says Herrup.

Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra ATP+, Double Strength Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map