ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Vitamin D supplements, sleep could help manage pain

Bacopa: The Herb That May Increase Your Brain Power

Eat More Yogurt and Avoid Osteoporosis

Lilac Oil: More Than Just for Fragrance

What Is Bilberry Good For?

Coffee, herbal tea may help prevent liver fibrosis

Crafty Uses for Carrot Seed Oil

Higher omega 3 levels linked to improved brain blood flow

Curcumin, resveratrol, ursolic acid show promise against prostate cancer

Olive oil compound could help protect against brain cancer

 
Print Page
Email Article

Common Anti-inflammatory Drug Fails to Slow Alzheimer's Disease

  [ 163 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 4, 2003


Hopes that naproxen, a nonsteroidal anti-inflammatory drug (NSAID), or rofecoxib, a COX-2 inhibitor, could slow the progression of Alzheimer's disease (AD) have been dashed as researchers at Georgetown University Medical Center report in the June 4 Journal of the American Medical Association that neither drug slows the cognitive deterioration that is the hallmark of AD. In addition, more adverse effects were reported in patients taking either drug as compared to the placebo group.

In the first NIH-funded, multicenter, placebo-controlled study of its kind, the Georgetown researchers set out to test the efficacy of low-dose naproxen (sold under the brand name Aleve®) and rofecoxib (sold under the name Vioxx®) in slowing cognitive decline in patients with mild-to-moderate AD. Abundant laboratory and epidemiological evidence pointed to these two drugs as potential effective therapeutic agents, given that inflammation is a key feature of AD.

Despite this encouraging body of evidence, neither drug held up under this new double-blinded, study. In the 351 patients enrolled in the 12-month study, placed either in the naproxen, rofecoxib, or placebo groups, neither active treatment had a beneficial effect on the mean change in score on the Alzheimer Disease Assessment Scale ? Cognitive subscale (ADAS-Cog). This test measures memory, attention, reasoning, language, orientation, and complex motor function. In fact, patients taking rofecoxib experienced more rapid cognitive decline than the naproxen and placebo groups.

"Based on this new research, these treatments cannot be recommended for use in clinical settings and should be suspended by any clinician who currently thinks NSAIDs stem the progression of AD," said Paul Aisen, M.D., Georgetown University professor of neurology and principal investigator of the study. "While the National Institute on Aging continues to explore the potential for NSAIDs to be effective preventive tools for AD, the fact remains that these results are not encouraging for those who are in need of an effective, immediate intervention."

In addition to observing ADAS-Cog scale scores, Dr. Aisen and his colleagues in the Alzheimer's Disease Cooperative Study Group examined the time interval from the baseline visit to attainment of one of five possible end points: death, institutionalization, increase in global clinical dementia rating, 15-point decline on the Alzheimer's Disease Cooperative Study activities of daily living scale, or four point decline on the ADAC-Cog scale.

Over the course of 12 months, 242 patients reached at least one end point, and regardless of whether people took naproxen, rofecoxib, or placebo, all patients attained an end point on the same time frame.

"With an aging American population, AD is poised to be one of the most trying, expensive, and disruptive public health issues on our horizon," said Dr. Aisen. "I'm disappointed that the promise of NSAIDs is not panning out, but remain hopeful that we will make inroads using other possible therapeutic options."

Alzheimer's Disease is a progressive neurological disorder that currently affects more than four million people. There is no known cure for AD. A disease associated with aging, the number of cases will continue to grow. According to the Alzheimer's Association, an estimated 14 million Americans will have AD by the middle of this century (2050) unless a cure or prevention is found.



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Optimized Curcumin Longvida® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map