ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

On-and-off fasting helps fight obesity, study finds

16 Tips from 16 Years Sick

Fibromyalgia Fare Fit for All Seasons

New Study Shows Artificial Sweeteners Lead to Diabetes

Essential Oils — An Effective and Healthy Option to Treat Headaches

Higher vitamin D levels associated with less severe disease in NAFLD patients

Can Pomegranates Slow Aging?

Krill Oil: Make This Omega-3 Supplement Part of Your Health Regimen

How zinc helps fight esophageal cancer

What Benefits Can You Get From High-Quality Whey Protein?

 
Print Page
Email Article

Downregulation of RNase L inhibitor correlates with upregulation of interferon-induced proteins (2-5A synthetase & RNase L) in patients with Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS)

  [ 60 votes ]   [ Discuss This Article ]
By Vojdani A, Choppa PC, Lapp CW • www.ProHealth.com • April 11, 1998


Chronic Fatigue Immune Dysfunction Syndrome (CFIDS) is a disorder
characterized by debilitating fatigue associated with
immunological abnormalities and cognitive impairments. The
recently cloned RNase L Inhibitor (RLI) gene encodes a
specific protein which is believed to regulate 2-5A synthetase
and RNase L activity via the formation of a latent
heterodimeric protein complex. In the present study, we
investigated the levels of 2-5A synthetase, RNase L and RLI in
patients with CFIDS as compared to healthy controls.

Quantitative Competitive PCR (Q/C PCR) analysis showed a
statistically significant decrease in RLI mRNA present in the
peripheral blood lymphocytes (PBL) of patients with CFIDS (n =
25, mean = 569, S.E = 154) as compared to RLI mRNA level
present in peripheral blood lymphocytes (PBL) of healthy
controls (n = 15, mean = 2296, S.E = 506; p < 0.0001). The
decrease in RLI mRNA in CFIDS individuals correlated directly
with RLI and RLI: RNase L protein ratio while showing an
inverse relationship to the 2-5A synthetase and RNase L
activity. This RLI mRNA and protein deficiency in CFIDS
patients may explain the increase in activity of RNase L found
in CFIDS patients. The unidirectional decrease in RLI message
and protein levels in CFIDS individuals may contribute to the
destabilization of the latent RLI:RNase L heterodimeric
protein complex, resulting in the excessive activation of
RNase L shown in this study. The increased activation of RNase
L may result in an increased cellular RNA turnover and
subsequent inhibition of protein synthesis; thus resulting in
general fatigue, myalgia muscle weakness and other
symptomatologies shown in CFIDS patients. Furthermore, this
data supports the hypothesis that the antiviral 2-5
oligoadenylate synthetase (2-5OAS) overexpression in
individuals with CFIDS correlates with an increase in RNase L
activity and with a decrease in RNase L inhibitor.




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Optimized Curcumin Longvida® FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map