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Current concepts in the pathophysiology of abnormal pain perception in fibromyalgia (FM)

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By Weigent DA, Bradley LA, Blalock JE, Alarcon GS • www.ProHealth.com • June 8, 1998


Fibromyalgia is a noninflammatory rheumatic disorder characterized
by chronic widespread musculoskeletal pain. Although many
studies have described the pain and other clinical symptoms
associated with this disorder, the primary mechanisms
underlying the etiology of fibromyalgia remain elusive. This
article reviews recent data supporting the links among each of
three systems--the musculoskeletal system, the neuroendocrine
system, and the central nervous system (CNS), all of which
appear to play major roles in fibromyalgia
pathophysiology--and pain in fibromyalgia, and concludes by
presenting a model of the pathophysiology of abnormal pain
perception in fibromyalgia which integrates the research
findings described.




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