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Natural killer cells & natural killer cell activity in Chronic Fatigue Syndrome (CFS)

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By Whiteside TL, Friberg D • www.ProHealth.com • September 28, 1998


Chronic fatigue syndrome (CFS) is associated with insidious and
persistent immunologic abnormalities that have proved
difficult to reproduce. The heterogeneity of CFS, the variable
quality of immunologic assays and their performance, along
with an almost complete absence of longitudinal studies of
cellular immune abnormalities in CFS may explain this
difficulty. However, in a significant proportion of cases, low
levels of natural killer (NK) cell activity have been
reported. This article will explore the mechanisms responsible
for low NK cell activity, discuss the relation between levels
of NK cell activity and health/disease, describe new findings
on NK cell-brain interactions, and put forth a specific
hypothesis for the role of NK cells in the pathogenesis of
CFS.




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