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Salivary cortisol profiles in Chronic Fatigue Syndrome (CFS)

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By Wood B, Wessely S, Papadopoulos A, Poon L, Checkley S • www.ProHealth.com • April 6, 1998


Salivary cortisol profiles (hourly sampling over a 16-hour period)
of 10 patients with chronic fatigue syndrome (CFS) but without
concurrent depressive disorder were compared with those of 10
healthy volunteers matched for age, sex and menstrual cycle.
The mean saliva cortisol concentration over the 16-hour period
was slightly but significantly greater in the patients than
the controls (p < 0.05). These findings are at variance with
earlier reports that CFS is a hypocortisolaemic state and
suggest that in CFS the symptom of fatigue is not caused by
hypocortisolaemia.




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