ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Omega Fix for Obesity: How the Right Fats Fight Fat

How Pomegranate May Protect Against Cancer

Potential of Quercetin in the Treatment of Melanoma

Trimming the spare tire: Canola oil may cut belly fat

Supplementation with vitamins C and E associated with decreased risk of cognitive impairment, dement...

 
Print Page
Email Article

Young People Prone to Type 2 Diabetes Exhibit Alterations in Mitochondrial Activity

  [ 143 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 16, 2004


New Haven, Conn. -- Researchers at Yale have found that decreased activity in muscle mitochondria, the powerhouses of the cell, may be a major factor in the development of type 2 diabetes in young, lean offspring of parents with the disease. They demonstrated a potential mechanism for the accumulation of fat in muscle cells of young, lean, insulin-resistant children of parents with type 2 diabetes by comparing them with insulin-sensitive control subjects matched for age, weight, height and activity. "There is a strong relationship between lipid content in the muscle and insulin resistance in skeletal muscle," said principal investigator Gerald I. Shulman, M.D., professor of internal medicine and cellular & molecular physiology at Yale School of Medicine. "Insulin resistance is the best predictor for whether someone will eventually develop type 2 diabetes." Using proton magnetic resonance spectroscopy (MRS), a safe, noninvasive method that does not involve any ionizing radiation, researchers found that insulin resistance in muscle of the diabetic offspring was accompanied by an increase in muscle cell lipid content. Shulman, an investigator at the Howard Hughes Medical Institute, led his group to distinguish whether the increase in muscle cell triglycerides was the result of increased delivery of fatty acids to muscle cells from the fat stored in "fat cells" (adipocytes), or the result of a decreased rate of fat oxidation by the mitochondria in the muscle cells. They measured rates of fatty acid release from adipocytes and found no differences between the two groups. In contrast, using phosphorus MRS they found a 30 percent reduction in the rate of mitochondrial energy production in the muscle of insulin resistant subjects compared to the control group. "These data support the hypothesis that insulin resistance in young, lean, healthy insulin resistant offspring of patients with type 2 diabetes may be due to an inherited defect that causes decreased mitochondrial activity and predisposes them to accumulate fat inside their muscle cells and develop insulin resistance," said Shulman. Shulman and his team are now investigating whether the decrease is due to a reduced number of mitochondria and/or reduced mitochondrial function and whether these abnormalities can be reversed with exercise training. "These results support the hypothesis that nuclear encoded genes that regulate mitochondrial biogenesis may be an important genetic cause of type 2 diabetes and that mitochondrial biogenesis represents a novel therapeutic target for treatment and possible prevention of type 2 diabetes," said Shulman. Other authors on the study included Kitt Falk Petersen, M.D., assistant professor of internal medicine at Yale; Sylvie Dufour, Douglas Befroy and Rina Garcia. Citation: New England Journal of Medicine, February 12, 2004; vol. 350, issue 7 pp. 664-71. Source: EurekAlert.org (this is a press release).



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® FibroSleep™ Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map