ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

More evidence for calorie restriction’s longevity effect

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Get the Most From Your Green Tea

Iron (And More) For Lasting, Natural Energy

Metabolic syndrome increases the need for vitamin E

Supplement combo improves bone density, mood, in postmenopausal women

 
Print Page
Email Article

Young People Prone to Type 2 Diabetes Exhibit Alterations in Mitochondrial Activity

  [ 143 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 16, 2004


New Haven, Conn. -- Researchers at Yale have found that decreased activity in muscle mitochondria, the powerhouses of the cell, may be a major factor in the development of type 2 diabetes in young, lean offspring of parents with the disease. They demonstrated a potential mechanism for the accumulation of fat in muscle cells of young, lean, insulin-resistant children of parents with type 2 diabetes by comparing them with insulin-sensitive control subjects matched for age, weight, height and activity. "There is a strong relationship between lipid content in the muscle and insulin resistance in skeletal muscle," said principal investigator Gerald I. Shulman, M.D., professor of internal medicine and cellular & molecular physiology at Yale School of Medicine. "Insulin resistance is the best predictor for whether someone will eventually develop type 2 diabetes." Using proton magnetic resonance spectroscopy (MRS), a safe, noninvasive method that does not involve any ionizing radiation, researchers found that insulin resistance in muscle of the diabetic offspring was accompanied by an increase in muscle cell lipid content. Shulman, an investigator at the Howard Hughes Medical Institute, led his group to distinguish whether the increase in muscle cell triglycerides was the result of increased delivery of fatty acids to muscle cells from the fat stored in "fat cells" (adipocytes), or the result of a decreased rate of fat oxidation by the mitochondria in the muscle cells. They measured rates of fatty acid release from adipocytes and found no differences between the two groups. In contrast, using phosphorus MRS they found a 30 percent reduction in the rate of mitochondrial energy production in the muscle of insulin resistant subjects compared to the control group. "These data support the hypothesis that insulin resistance in young, lean, healthy insulin resistant offspring of patients with type 2 diabetes may be due to an inherited defect that causes decreased mitochondrial activity and predisposes them to accumulate fat inside their muscle cells and develop insulin resistance," said Shulman. Shulman and his team are now investigating whether the decrease is due to a reduced number of mitochondria and/or reduced mitochondrial function and whether these abnormalities can be reversed with exercise training. "These results support the hypothesis that nuclear encoded genes that regulate mitochondrial biogenesis may be an important genetic cause of type 2 diabetes and that mitochondrial biogenesis represents a novel therapeutic target for treatment and possible prevention of type 2 diabetes," said Shulman. Other authors on the study included Kitt Falk Petersen, M.D., assistant professor of internal medicine at Yale; Sylvie Dufour, Douglas Befroy and Rina Garcia. Citation: New England Journal of Medicine, February 12, 2004; vol. 350, issue 7 pp. 664-71. Source: EurekAlert.org (this is a press release).



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Vitamin D3 Extreme™ Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map