ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

A Little Zinc Goes a Long Way

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Iron (And More) For Lasting, Natural Energy

Get the Most From Your Green Tea

Affordable Care Act made cancer screening more accessible for millions, study finds

Metabolic syndrome increases the need for vitamin E

 
Print Page
Email Article

Hypothalamic-pituitary-insulin-like growth factor-I axis dysfunction in patients with fibromyalgia (FM)

  [ 25 votes ]   [ Discuss This Article ]
By Bennett RM, Cook DM, Clark SR, Burckhardt CS, Campbell SM • www.ProHealth.com • July 5, 1997


OBJECTIVE: To investigate the serum levels of insulin-like growth
factor-I (IGF-I) in patients with fibromyalgia (FM) compared
to healthy controls and patients with other rheumatic
diseases, and to explore possible etiologic mechanisms of low
IGF-I levels in patients with FM.

METHODS: Five hundred
patients with FM and 152 controls (74 healthy blood donors, 26
myofascial pain patients and 52 patients with other rheumatic
diseases) were studied. All had measurements of acid extracted
serum IGF-I. A subset of 90 patients with FM were evaluated
for clinical features that might explain low IGF-I levels.
Twenty-five patients with FM underwent growth hormone (GH)
provocation testing with l-dopa and clonidine.

RESULTS: The
mean serum IGF-I level in patients with FM was 138 +/- 56
ng/ml and in controls 215 +/- 86 ng/ml (p = 0.00000000001).
Low levels of IGF-I were not due to depression, tricyclic
medications, nonsteroidal antiinflammatory drugs, poor aerobic
conditioning, obesity, or pain level. Patients with focal
myofascial pain syndromes had normal IGF-I levels (236 +/-
68), as did most patients with other rheumatic disorders,
unless they had concomitant FM. Patients with FM with
initially normal levels often had a rapid decline of IGF-I
over 1 to 2 years. Most patients with FM with low IGF-I levels
failed to secrete GH after stimulation with clonidine and
l-dopa.

CONCLUSION: Many, but not all, patients with FM have
low levels of IGF-I that cannot be explained by clinical
associations. These results suggest that low IGF-I levels in
patients with FM are a secondary phenomenon due to
hypothalamic-pituitary-GH axis dysfunction.




Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Optimized Curcumin Longvida® Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map