ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Scientifically-designed fasting diet lowers risks for major diseases

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

A Little Zinc Goes a Long Way

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Get the Most From Your Green Tea

Iron (And More) For Lasting, Natural Energy

Metabolic syndrome increases the need for vitamin E

Supplement combo improves bone density, mood, in postmenopausal women

 
Print Page
Email Article

Interleukin-1 beta, interleukin-1 receptor antagonist, & soluble interleukin-1 receptor type II secretion in Chronic Fatigue Syndrome (CFS)

  [ 85 votes ]   [ Discuss This Article ]
By Cannon J,Angel J,Abad L, Vannier E, Mileno M, Fagioli L, Wolff S, Komaroff A • www.ProHealth.com • May 16, 1997


Chronic fatigue syndrome is a condition that affects women in
disproportionate numbers, and that is often exacerbated in the
premenstrual period and following physical exertion. The signs
and symptoms, which include fatigue, myalgia, and low-grade
fever, are similar to those experienced by patients infused
with cytokines such as interleukin-1.

The present study was carried out to test the hypotheses that (1)
cellular secretion of interleukin-1 beta (IL-1 beta), interleukin-1
receptor antagonist (IL-1Ra), and soluble interleukin-1 receptor
type II (IL-1sRII) is abnormal in female CFS patients compared
to age- and activity-matched controls; (2) that these
abnormalities may be evident only at certain times in the
menstrual cycle; and (3) that physical exertion (stepping up
and down on a platform for 15 min) may accentuate differences
between these groups.

Isolated peripheral blood mononuclear cells from healthy #
women, but not CFS patients, exhibited significant
menstrual cycle-related differences in IL-1 beta
secretion that were related to estradiol and progesterone
levels (R2 = 0.65, P < 0.01). IL-1Ra secretion for CFS
patients was twofold higher than controls during the
follicular phase (P = 0.023), but luteal-phase levels were
similar between groups. In both phases of the menstrual cycle,
IL-1sRII release was significantly higher for CFS patients
compared to controls (P = 0.002). The only changes that might
be attributable to exertion occurred in the control subjects
during the follicular phase, who exhibited an increase in IL-1
beta secretion 48 hr after the stress (P = 0.020).

These results suggest that an abnormality exists in IL-1 beta
secretion in CFS patients that may be related to altered
sensitivity to estradiol and progesterone. Furthermore, the
increased release of IL-1Ra and sIL-1RII by cells from CFS
patients is consistent with the hypothesis that CFS is
associated with chronic, low-level activation of the immune
system.




Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Energy NADH™ 12.5mg FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
"It's Not Easy Being Green" - But It Is Healthy

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map