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Caregivers refuse Alzheimer’s medications when patient’s quality of life threatened

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www.ProHealth.com • October 3, 2003


Caregiver assessment is key to clinical outcomes for Alzheimer’s patients and to determining when is the time to end treatment

(Philadelphia, PA) – A caregiver's assessment of an Alzheimer's patient's quality of life is the key factor in determining if and why some caregivers decline to use a treatment that slows progression of the patient's disease, according to a new study from researchers at the Institute on Aging at the University of Pennsylvania School of Medicine.

Their findings – set for publication in the October 3rd edition of the Journal of the American Geriatric Society – reveal that caregivers are most likely to decline medications slowing Alzheimer's disease if the caregiver assesses the patient's overall quality of life as fair or poor. For example, a husband may decline treatment of his spouse when she can no longer remember family members and can only communicate with them as strangers. When there is risk to the medication, the number of caregivers who decline treatment rises substantially.

"Caregivers have always played a vital role in providing direct care. That is why we call them caregivers. They also make decisions for patients," said Jason Karlawish, MD, an Assistant Professor of Medicine in Geriatrics at Penn's School of Medicine and lead author of the study. "In fact, by the moderate to severe stages of the disease, caregivers make most of the treatment decisions, including when to say 'no' to a particular therapy."

The two-year study evaluated 102 caregivers of patients with mild to severe stages of Alzheimer's disease. Seventeen percent of these caregivers did not want their relatives to take a risk-free medication that could slow the disease, and half of the caregivers did not want their relatives to take medication with a risk of side effects (a three percent risk of gastro-intestinal bleeding.)

Patients were evaluated using interviews that assessed the severity of their dementia. Quality of life was measured using both a single question to assess overall quality of life, and a 13-point scale that measured, among other things – physical health, energy, mood, memory, and the ability to do chores, have fun, and interact with family and friends.

Among the other key study findings were that a caregiver's characteristics – mental health, financial burden and race – also drove their decision to decline a treatment when there was a risk or side-effect to the treatment. Caregivers suffering from depression – which can be a result of the stress and burden of caregiving – were more likely to decline a treatment. Financial burden and race were also factors more likely to lead to declining treatment: study participants who ranked themselves as having "just enough" or "not enough" funds at the end of the month were more likely to decline treatment, where prescriptions can cost a few hundred dollars per month; non-whites were also more likely to decline treatment, although no data confirmed why this was the case.

"Understandably, we focus on starting treating early. But we need to think about the other side of treatment – stopping it. Now that we understand why caregivers refuse a dementia-slowing treatment, we can better plan for patient care and develop future treatment guidelines that incorporates the caregiver's experience," said Karlawish. "This planning could ultimately help caregivers and physicians in determining an appropriate time to end treatment for Alzheimer's disease, based on factors influencing quality of life. It also shows that managing the health of the caregiver is an integral part to treating a patient with Alzheimer's disease. When you have one person with Alzheimer's disease, you have at least two people to take care of."

Funding for this study was provided through a Paul Beeson Physician Faculty Scholars Award and the National Institute on Aging.

It is estimated that about five million Americans are currently living with Alzheimer's disease. Another 360,000 new cases are diagnosed each year. The number of Americans living with Alzheimer's disease is projected to increase to 16 million over the next 50 years. Annual costs for direct medical care of a patient with Alzheimer's disease are estimated at $50,000. Current treatments used to slow the progression of the disease include Vitamin E and cholinesterase inhibitors – Aricept, Exelon and, possibly, Memantine (which is currently under review by the Food and Drug Administration.) However, each treatment has limitations: all are minimally effective for the most severe stages of Alzheimer's disease, and each has different side effects.

Editor's Note:

You may also find this news release on-line at www.uphs.upenn.edu/news PENN Medicine is a $2.2 billion enterprise dedicated to the related missions of medical education, biomedical research, and high-quality patient care. PENN Medicine consists of the University of Pennsylvania School of Medicine (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System (created in 1993 as the nation's first integrated academic health system). Penn's School of Medicine is ranked #2 in the nation for receipt of NIH research funds; and ranked #4 in the nation in U.S. News & World Report's most recent ranking of top research-oriented medical schools. Supporting 1,400 fulltime faculty and 700 students, the School of Medicine is recognized worldwide for its superior education and training of the next generation of physician-scientists and leaders of academic medicine.

Penn Health System consists of four hospitals (including its flagship Hospital of the University of Pennsylvania, consistently rated one of the nation's "Honor Roll" hospitals by U.S. News & World Report), a faculty practice plan, a primary-care provider network, three multispecialty satellite facilities, and home health care and hospice.



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