ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

Print Page
Email Article

Down Syndrome Study Reveals Possible Method for Detecting Initial Stages of Alzheimer’s

  [ 20 votes ]   [ Discuss This Article ] • December 23, 2003

Brain scans show increased metabolism by neural cells when battling onset of degenerative disease

Irvine, Calif. -- UC Irvine College of Medicine researchers conducting the first longitudinal brain imaging study of adults with Down syndrome may have found a way to detect Alzheimer's disease before symptoms of dementia begin to set in.

In the study, brain scans of adults with Down syndrome showed increased metabolic activity in the temporal cortex – the same region of the brain where Alzheimer's disease commonly develops. The researchers speculate that Alzheimer's may begin with a similar metabolic increase, because Down syndrome often leads to dementia during adulthood

If so, a common PET scan procedure could allow early detection of Alzheimer's.

Study results appear in the Dec. 23 issue of Neurology.

According to Richard Haier, professor of pediatrics and principal investigator of the study, neurons work efficiently in normal brains, but in diseased brains, damaged neurons have to work harder to maintain their effectiveness, as revealed by the metabolic rate increases in Down syndrome brains. This damage most likely comes from the progressive accumulation of both senile plaques and neurofibrillary tangles, the two lesions associated with both Down syndrome and Alzheimer's. When the damaged neurons are ultimately destroyed by these lesions, the metabolic rate will decrease, as was observed in the Alzheimer's-diseased brains scanned for the study.

"These findings suggest that Down syndrome dementia and possibly Alzheimer's disease may begin when neuronal damage in the temporal cortex region reaches the point where increased metabolism can no longer compensate," Haier said. "But to confirm this, further imaging tests must be done on the Down syndrome people as dementia progresses."

Nearly 350,000 Americans have Down syndrome, which is a genetic disorder caused by the inheritance of three copies of the 21st chromosome. People with Down syndrome show some of the brain changes of Alzheimer's as early as age 12. Nearly all Down syndrome patients have the brain changes of Alzheimer's disease by age 40. Despite this, not all individuals with Down syndrome develop symptoms of the disorder.

The National Institute of Child Health and Development is providing funding for this study.

Dr. Michael Alkire, Nathan White, Melina Uncapher, Elizabeth Head, Dr. Ira Lott and Carl Cotman of UCI assisted Haier with the study.

About the University of California, Irvine: The University of California, Irvine is a top-ranked public university dedicated to research, scholarship and community. Founded in 1965, UCI has more than 23,000 undergraduate and graduate students and about 1,300 faculty members. The third-largest employer in dynamic Orange County, UCI contributes an annual economic impact of $3 billion.

UCI maintains an online directory of faculty available as experts to the media. To access, visit:

Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® FibroSleep™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map