ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

A Breathalyzer for Disease?

Why You Should Be Eating More Porcini Mushrooms

Tryptophan's Possible Effects for Your Health

How Bacopa Can Help Improve Your Cognitive Function

Black Tea Is Great for Your Gut

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Mint: Learn More About This Refreshing and Invigorating Herb

 
Print Page
Email Article

Researchers find key to reducing arthritis inflammation

  [ 6 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 29, 2000


A protein that reduces inflammation has been discovered by a group of researchers at the University of British Columbia (UBC). Their findings may pave the way for new treatments for many chronic inflammatory diseases, including arthritis.

Researchers discovered how the human body uses a natural signal - called MCP-3 - to turn off inflammation while studying how cancer cells spread.

"MCP-3 is like a traffic signal with a green and red light that tells the macrophages -- white blood cells that rid the body of damaged tissue -- when and where to go," said Professor Chris Overall, of UBC’s Faculty of Dentistry. "Like any accident, it is important to get help, but when everything is fixed, the body then needs to be told to stop sending more 'ambulances' to the problem spot, or else things clog up and break down again."

Overall explained that in chronic diseases like arthritis something goes wrong with the signals and the flow of white blood cells continues, leading to chronic inflammation and long-term tissue damage.

Angus McQuibban, a UBC biochemistry doctoral student working in Overall's lab, discovered a new form of MCP-3 that halts the flow of the white blood cells. He found that an enzyme called gelatinase made during inflammation trimmed the end of MCP-3 molecules and led to the new form of the protein.

McQuibban likens it to shooting out the green light on a traffic signal. "There is now no more signal. But we had a bigger surprise to find that not only was the 'green light' removed, but that the 'red light' then came on. Now the movement of these cells was stopped."

Tests revealed that there was a 40 per cent reduction in inflammation when the new form of MCP-3 was administered. Prof. Ian Clark-Lewis at UBC's Biomedical Research Centre synthesized the new form of MCP-3 for testing by Prof. Chris McCullouch at the University of Toronto's Faculty of Dentistry.

"What we are trying to do now is to work out how these signals go wrong in diseases like cancer, arthritis and periodontitis with the hope we can understand in molecular detail these very complicated processes that may lead to new drug discoveries," said Overall. The researchers’ findings are to be reported in the journal Science.

In the meantime, the new form of MCP-3 has been patented at UBC and is being evaluated as a new anti-inflammatory drug.



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra EPA  - Fish Oil Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map